Author: O Milhavet | MedLuna.com

1.

Gene and cell therapy for prion diseases

Relano-Gines A, Gabelle A, Lehmann S, Milhavet O, Crozet C

Infect Disord Drug Targets . 2009 Feb; 9(1):58-68. PMID: 19200016

Prion diseases are neurodegenerative disorders characterized by the accumulation of an abnormal prion protein named PrP(Sc). PrP(Sc) results from the post-translational conformational modification of the host-encoded protein PrP(C). To date...

2.

p38 MAP kinase mediates nitric oxide-induced apoptosis of neural progenitor cells

Cheng A, Chan S, Milhavet O, Wang S, Mattson M

J Biol Chem . 2001 Sep; 276(46):43320-7. PMID: 11555660

Neural progenitor cells (NPC) can proliferate, differentiate into neurons or glial cells, or undergo a form of programmed cell death called apoptosis. Although death of NPC occurs during development of...

3.

Prion infection impairs the cellular response to oxidative stress

Milhavet O, McMAHON H, Rachidi W, Nishida N, Katamine S, Mange A, et al.

Proc Natl Acad Sci U S A . 2000 Nov; 97(25):13937-42. PMID: 11095725

The molecular mechanism of neurodegeneration in transmissible spongiform encephalopathies remains uncertain. In this study, it was demonstrated that prion-infected hypothalamic neuronal GT1 cells displayed a higher sensitivity to induced oxidative...

4.

Amphotericin B inhibits the generation of the scrapie isoform of the prion protein in infected cultures

Mange A, Nishida N, Milhavet O, McMAHON H, Casanova D, Lehmann S

J Virol . 2000 Mar; 74(7):3135-40. PMID: 10708429

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative disorders that have the unique property of being infectious, sporadic, or genetic in origin. Although some doubts about the nature of...

5.

Effect of amphotericin B on wild-type and mutated prion proteins in cultured cells: putative mechanism of action in transmissible spongiform encephalopathies

Mange A, Milhavet O, McMAHON H, Casanova D, Lehmann S

J Neurochem . 2000 Jan; 74(2):754-62. PMID: 10646527

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative disorders that have the unique property of being infectious, sporadic, or genetic in origin. Although some doubts remain on the nature...

6.

Effect of Congo red on wild-type and mutated prion proteins in cultured cells

Milhavet O, Mange A, Casanova D, Lehmann S

J Neurochem . 2000 Jan; 74(1):222-30. PMID: 10617123

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative disorders that have the unique property of being infectious, sporadic, or genetic in origin. Although some doubts remain on the nature...

7.

Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein

Nishida N, Harris D, Vilette D, Laude H, Frobert Y, Grassi J, et al.

J Virol . 1999 Dec; 74(1):320-5. PMID: 10590120

Propagation of the agents responsible for transmissible spongiform encephalopathies (TSEs) in cultured cells has been achieved for only a few cell lines. To establish efficient and versatile models for transmission,...

8.

Trafficking of the cellular isoform of the prion protein

Lehmann S, Milhavet O, Mange A

Biomed Pharmacother . 1999 Apr; 53(1):39-46. PMID: 10221167

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative disorders that have the unique property of being infectious, sporadic or genetic in origin. Although the nature of the responsible agent...