O M Rosen
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Explore the profile of O M Rosen including associated specialties, affiliations and a list of published articles.
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150
Citations
3000
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Recent Articles
1.
Fischbarg J, Cheung M, Czegledy F, Li J, Iserovich P, Kuang K, et al.
Proc Natl Acad Sci U S A
. 1993 Dec;
90(24):11658-62.
PMID: 8265604
A widely accepted model for the structure of the facilitative glucose transporters (GLUTs) predicts that they form 12 transmembrane alpha-helices and that the highly conserved sequence Ile-386-Ala-405 in GLUT1 is...
2.
Ahn J, Rosen O, Donner D
J Biol Chem
. 1993 Aug;
268(22):16839-44.
PMID: 8393875
Phosphorylation of threonine 1336 of the human insulin receptor (HIR) is stimulated by insulin or 4 beta-phorbol 12-myristate 13-acetate in Chinese hamster ovary (CHO) transfectant cells expressing the wild type...
3.
Ahn J, Donner D, Rosen O
J Biol Chem
. 1993 Apr;
268(10):7571-6.
PMID: 8463287
The cytoplasmic domain of the human insulin receptor (HIR) from the baculovirus expression system (BIRK) is a soluble, constitutively activated protein-tyrosine kinase. In a cell-free system, BIRK is phosphorylated on...
4.
Murakami M, Rosen O
J Biol Chem
. 1991 Nov;
266(33):22653-60.
PMID: 1658004
We have examined the role of autophosphorylation in insulin signal transmission by oligonucleotide directed mutagenesis of seven potential tyrosine autophosphorylation sites in the human insulin receptor. Chinese hamster ovary cells...
5.
Rapuano M, Rosen O
J Biol Chem
. 1991 Jul;
266(20):12902-7.
PMID: 1649167
A serine protein kinase that phosphorylates the beta-subunit of the insulin receptor has been partially purified 5,000-fold from HeLa cell membranes. The enzyme has been purified by ion-exchange and hydroxylapatite...
6.
Vera J, Castillo G, Rosen O
Mol Cell Biol
. 1991 Jul;
11(7):3407-18.
PMID: 1675425
We show that D- but not L-hexoses modulate the accumulation of radioactive vinblastine in injected Xenopus laevis oocytes expressing the murine Mdr1b P-glycoprotein. We also show that X. laevis oocytes...
7.
Majumdar S, Rossi M, Fujiki T, Phillips W, DIsa S, Queen C, et al.
J Biol Chem
. 1991 May;
266(14):9285-94.
PMID: 2026625
Neutrophils possess a classical Ca2+, phosphatidyl serine (PS) and diglyceride (DG)-dependent protein kinase C (beta-PKC) which was translocatable from cytosol to membrane in response to elevated Ca2+ in the physiologic...
8.
Lebwohl D, Nunez I, Chan M, Rosen O
J Biol Chem
. 1991 Jan;
266(1):386-90.
PMID: 1845969
We have transfected mouse L cells with a recombinant membrane-anchored insulin receptor kinase (called MARK), under the transcriptional control of a glucocorticoid-responsive element. The transfected construct includes only 15 extracellular...
9.
Castillo G, Vera J, Yang C, Horwitz S, Rosen O
Proc Natl Acad Sci U S A
. 1990 Jun;
87(12):4737-41.
PMID: 1693776
The development of multidrug resistance (MDR) is associated with the overproduction of a plasma membrane glycoprotein, P glycoprotein. Here we report the functional expression of a member of the murine...
10.
Fischbarg J, Kuang K, Vera J, Arant S, Silverstein S, Loike J, et al.
Proc Natl Acad Sci U S A
. 1990 Apr;
87(8):3244-7.
PMID: 2326282
Water traverses the plasma membranes of some eukaryotic cells faster than can be explained by the water permeability of their lipid bilayers. This has led to a search for a...