O J Sansom
Overview
Explore the profile of O J Sansom including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
29
Citations
822
Followers
0
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Related Specialties
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Recent Articles
1.
Pickering K, Gilroy K, Cassidy J, Fey S, Najumudeen A, Zeiger L, et al.
Nat Commun
. 2021 Jan;
12(1):56.
PMID: 33397922
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of...
2.
Wilson D, Jarman E, Mellin R, Wilson M, Waddell S, Tsokkou P, et al.
Nat Commun
. 2020 Jan;
11(1):445.
PMID: 31974352
The number of patients diagnosed with chronic bile duct disease is increasing and in most cases these diseases result in chronic ductular scarring, necessitating liver transplantation. The formation of ductular...
3.
Dreyer S, Jamieson N, Morton J, Sansom O, Biankin A, Chang D
Clin Oncol (R Coll Radiol)
. 2019 Sep;
32(1):5-8.
PMID: 31522943
No abstract available.
4.
Flanagan D, Hodder M, Sansom O
Nat Cell Biol
. 2018 Sep;
20(10):1102-1104.
PMID: 30258126
No abstract available.
5.
Ferro R, Adamska A, Lattanzio R, Mavrommati I, Edling C, Arifin S, et al.
Oncogene
. 2018 Aug;
37(49):6368-6382.
PMID: 30061636
The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five...
6.
Huels D, Bruens L, Hodder M, Cammareri P, Campbell A, Ridgway R, et al.
Nat Commun
. 2018 Mar;
9(1):1132.
PMID: 29556067
Many epithelial stem cell populations follow a pattern of stochastic stem cell divisions called 'neutral drift'. It is hypothesised that neutral competition between stem cells protects against the acquisition of...
7.
Monteverde T, Tait-Mulder J, Hedley A, Knight J, Sansom O, Murphy D
Oncogene
. 2017 Nov;
37(8):982-992.
PMID: 29106388
NUAK1 is a member of the AMPK-related family of kinases. Recent evidence suggests that NUAK1 is an important regulator of cell adhesion and migration, cellular and organismal metabolism, and regulation...
8.
Wildenberg M, Koelink P, Diederen K, Te Velde A, Wolfkamp S, Nuij V, et al.
Mucosal Immunol
. 2016 Jul;
10(2):352-360.
PMID: 27435106
Thiopurines are commonly used drugs in the therapy of Crohn's disease, but unfortunately only show a 30% response rate. The biological basis for the thiopurine response is unclear, thus hampering...
9.
Huels D, Sansom O
Br J Cancer
. 2015 Jun;
113(1):1-5.
PMID: 26110974
Colorectal cancer (CRC) is one of the most common cancers in the western world and is characterised by deregulation of the Wnt signalling pathway. Mutation of the adenomatous polyposis coli...
10.
Meniel V, Megges M, Young M, Cole A, Sansom O, Clarke A
Oncogene
. 2014 Oct;
34(31):4118-29.
PMID: 25347740
Disruption of Apc (adenomatous polyposis coli) within hepatocytes activates Wnt signalling, perturbs differentiation and ultimately leads to neoplasia. Apc negatively regulates Wnt signalling but is also involved in organizing the...