H Y Leung
Overview
Explore the profile of H Y Leung including associated specialties, affiliations and a list of published articles.
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Articles
61
Citations
1292
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0
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Recent Articles
1.
McAteer M, OConnor J, Koh D, Leung H, Doran S, Jauregui-Osoro M, et al.
Br J Cancer
. 2021 Jul;
125(11):1462-1465.
PMID: 34316019
The National Cancer Imaging Translational Accelerator (NCITA) is creating a UK national coordinated infrastructure for accelerated translation of imaging biomarkers for clinical use. Through the development of standardised protocols, data...
2.
Salji M, Jones R, Paul J, Birrell F, Dixon-Hughes J, Hutchison C, et al.
Br J Cancer
. 2014 Jun;
111(3):424-9.
PMID: 24946001
Background: Salvage therapeutic options for biochemical failure after primary radiation-based therapy include radical prostatectomy, cryoablation, high-intensity focused ultrasound (HIFU), brachytherapy (for post-EBRT patients) and androgen deprivation therapy (ADT). ADT and...
3.
Williamson S, Mitter R, Hepburn A, Wilson L, Mantilla A, Leung H, et al.
Br J Cancer
. 2013 Jul;
109(4):950-6.
PMID: 23880823
Background: Evidence increasingly supports that prostate cancer is initiated by the malignant transformation of stem cells (SCs). Furthermore, many SC-signalling pathways are shown to be shared in prostate cancer. Therefore,...
4.
Ahmad I, Singh L, Yang Z, Kalna G, FLEMING J, Fisher G, et al.
Br J Cancer
. 2013 Jan;
108(1):149-54.
PMID: 23321517
Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)-extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (CaP). The mechanism for ERK5...
5.
Willder J, Heng S, McCall P, Adams C, Tannahill C, Fyffe G, et al.
Br J Cancer
. 2013 Jan;
108(1):139-48.
PMID: 23321516
Background: Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation...
6.
McCall P, Bennett L, Ahmad I, Mackenzie L, Forbes I, Leung H, et al.
Br J Cancer
. 2012 Oct;
107(9):1554-63.
PMID: 23093296
Background: Cell line models suggest that activation of NFκB is associated with progression of prostate cancer. This pathway may be a therapeutic target if these observations translate to clinical specimens....
7.
Armstrong K, Ahmad I, Kalna G, Tan S, Edwards J, Robson C, et al.
Br J Cancer
. 2011 Sep;
105(9):1362-9.
PMID: 21952621
Background: Prostate cancer (PC) represents a global health issue. Treatment for locally advanced and metastatic PC remains unsatisfactory. The androgen receptor (AR) has been validated in having a key role...
8.
Ahmad I, Patel R, Liu Y, Singh L, Taketo M, Wu X, et al.
Cell Death Dis
. 2011 Mar;
2:e124.
PMID: 21368895
Mutations in the Ras family of proteins (predominantly in H-Ras) occur in approximately 40% of urothelial cell carcinoma (UCC). However, relatively little is known about subsequent mutations/pathway alterations that allow...
9.
Bennett H, Fleming J, OPrey J, Ryan K, Leung H
Cell Death Dis
. 2011 Mar;
1:e72.
PMID: 21364676
Pro-survival signalling mediated by the androgen receptor (AR) is implicated as a key contributor to prostate carcinogenesis. As prostate tumours are characterized by nutrient-poor, hypoxic and acidified microenvironments, one mechanism...
10.
Ramsay A, McCracken S, Soofi M, FLEMING J, Yu A, Ahmad I, et al.
Br J Cancer
. 2011 Jan;
104(4):664-72.
PMID: 21266977
Background: Aberrant mitogen/extracellular signal-regulated kinase 5 (MEK5)-extracellular signal-regulated protein kinase 5 (ERK5)-mediated signalling has been implicated in a number of tumour types including prostate cancer (PCa). The molecular basis of...