Novin Balafkan
Overview
Explore the profile of Novin Balafkan including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
151
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Recent Articles
1.
Mostafavi S, Balafkan N, Pettersen I, Nido G, Siller R, Tzoulis C, et al.
Front Cell Dev Biol
. 2021 Nov;
9:744777.
PMID: 34722525
Given the considerable interest in using stem cells for modeling and treating disease, it is essential to understand what regulates self-renewal and differentiation. Remodeling of mitochondria and metabolism, with the...
2.
Balafkan N, Mostafavi S, Schubert M, Siller R, Liang K, Sullivan G, et al.
Sci Rep
. 2020 Oct;
10(1):18498.
PMID: 33116175
The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell type have made them a powerful tool for studying human disease. Protocols for efficient differentiation...
3.
Liang K, Kristiansen C, Mostafavi S, Vatne G, Zantingh G, Kianian A, et al.
EMBO Mol Med
. 2020 Aug;
12(10):e12146.
PMID: 32840960
Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient...
4.
Bhatt P, Tzoulis C, Balafkan N, Miletic H, Tran G, Sanaker P, et al.
Neuromuscul Disord
. 2019 Mar;
29(3):242-246.
PMID: 30850168
Sporadic inclusion body myositis (sIBM) is a late onset disorder of unkown aetiology. Mitochondrial changes such as cytochrome oxidase deficient fibres are a well recognised feature and mitochondrial DNA (mtDNA)...
5.
Tzoulis C, Tran G, Coxhead J, Bertelsen B, Lilleng P, Balafkan N, et al.
Ann Neurol
. 2014 May;
76(1):66-81.
PMID: 24841123
Objective: Polymerase gamma (POLG) mutations are a common cause of mitochondrial disease and have also been linked to neurodegeneration and aging. We studied the molecular mechanisms underlying POLG-related neurodegeneration using...
6.
Tzoulis C, Tran G, Schwarzlmuller T, Specht K, Haugarvoll K, Balafkan N, et al.
Brain
. 2013 Apr;
136(Pt 8):2393-404.
PMID: 23625061
The role of mitochondria in the pathogenesis of neurodegeneration is an area of intense study. It is known that defects in proteins involved in mitochondrial quality control can cause Parkinson's...
7.
Balafkan N, Tzoulis C, Muller B, Haugarvoll K, Tysnes O, Larsen J, et al.
Mitochondrion
. 2012 Sep;
12(6):640-3.
PMID: 22963882
The number of CAG repeats in the mitochondrial DNA-polymerase gamma (POLG1) gene has been associated with Parkinson disease (PD) in some populations. We sequenced the CAG tract of POLG1 in...