Nouran S Abdelfattah
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Explore the profile of Nouran S Abdelfattah including associated specialties, affiliations and a list of published articles.
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9
Citations
439
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Recent Articles
1.
Lagattuta K, Kohlgruber A, Abdelfattah N, Nathan A, Rumker L, Birnbaum M, et al.
Cell Rep
. 2024 Dec;
44(1):115098.
PMID: 39731734
The amino acid sequence of the T cell receptor (TCR) varies between T cells of an individual's immune system. Particular TCR residues nearly guarantee mucosal-associated invariant T (MAIT) and natural...
2.
Abdelfattah N, Kula T, Elledge S
Immunity
. 2024 Dec;
57(12):2945-2958.e5.
PMID: 39631392
Many promising targets for adoptive T cell therapy (ACT) are self-antigens, but self-reactive T cells are generally eliminated during thymic selection or diverted to regulatory phenotypes. To bypass T cell...
3.
Bruno P, Timms R, Abdelfattah N, Leng Y, Lelis F, Wesemann D, et al.
Nat Biotechnol
. 2023 Jan;
41(7):980-992.
PMID: 36593401
Identification of CD8 T cell epitopes is critical for the development of immunotherapeutics. Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery are time intensive, specialized...
4.
Kula T, Dezfulian M, Wang C, Abdelfattah N, Hartman Z, Wucherpfennig K, et al.
Cell
. 2019 Aug;
178(4):1016-1028.e13.
PMID: 31398327
T cell recognition of specific antigens mediates protection from pathogens and controls neoplasias, but can also cause autoimmunity. Our knowledge of T cell antigens and their implications for human health...
5.
Abdelfattah N, Mullally A
J Vis Exp
. 2018 Jan;
(131).
PMID: 29364275
Clustered regularly interspaced short palindromic repeats (CRISPR) is an adaptive immunity system in prokaryotes that has been repurposed by scientists to generate RNA-guided nucleases, such as CRISPR-associated (Cas) 9 for...
6.
Elf S, Abdelfattah N, Baral A, Beeson D, Rivera J, Ko A, et al.
Blood
. 2017 Dec;
131(7):782-786.
PMID: 29288169
Mutations in calreticulin () are phenotypic drivers in the pathogenesis of myeloproliferative neoplasms. Mechanistic studies have demonstrated that mutant CALR binds to the thrombopoietin receptor MPL, and that the positive...
7.
Lobbardi R, Pinder J, Martinez-Pastor B, Theodorou M, Blackburn J, Abraham B, et al.
Cancer Discov
. 2017 Oct;
7(11):1336-1353.
PMID: 28974511
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Using a transgenic screen in zebrafish, thymocyte selection-associated high mobility group box protein (TOX) was uncovered as a collaborating...
8.
Elf S, Abdelfattah N, Chen E, Perales-Paton J, Rosen E, Ko A, et al.
Cancer Discov
. 2016 Mar;
6(4):368-81.
PMID: 26951227
Unlabelled: Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is oncogenic remains unclear. Here, we...
9.
Tang Q, Abdelfattah N, Blackburn J, Moore J, Martinez S, Moore F, et al.
Nat Methods
. 2014 Jul;
11(8):821-4.
PMID: 25042784
Cell transplantation into adult zebrafish has lagged behind mouse models owing to the lack of immunocompromised strains. Here we have created rag2(E450fs) mutant zebrafish that have reduced numbers of functional...