Norman R Saunders
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Explore the profile of Norman R Saunders including associated specialties, affiliations and a list of published articles.
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64
Citations
2006
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Recent Articles
11.
Toll S, Qiu F, Huang Y, Habgood M, Dziegielewska K, Nie S, et al.
F1000Res
. 2021 Aug;
10:384.
PMID: 34249340
Women with epilepsy face difficult choices whether to continue antiepileptic drug treatment during pregnancy, as uncontrolled seizures carry great risk to mother and fetus but continuing treatment may have adverse...
12.
Koehn L, Dziegielewska K, Habgood M, Huang Y, Saunders N
Fluids Barriers CNS
. 2021 Feb;
18(1):6.
PMID: 33557872
Background: Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal fluid...
13.
Koehn L, Huang Y, Habgood M, Kysenius K, Crouch P, Dziegielewska K, et al.
F1000Res
. 2020 Sep;
9:573.
PMID: 32934805
Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as "safe" by regulatory authorities. Clinically relevant doses of paracetamol were administered intraperitoneally to pregnant rats twice daily from embryonic...
14.
Medications for pregnant women: A balancing act between the interests of the mother and of the fetus
Saunders N, Dziegielewska K
Prenat Diagn
. 2020 Apr;
40(9):1156-1167.
PMID: 32335932
Drug entry into the adult brain is controlled by efflux mechanisms situated in various brain barrier interfaces. The effectiveness of these protective mechanisms in the embryo, fetus and newborn brain...
15.
Koehn L, Dziegielewska K, Mollgard K, Saudrais E, Strazielle N, Ghersi-Egea J, et al.
Sci Rep
. 2019 Apr;
9(1):5998.
PMID: 30979952
Many pregnant women and prematurely born infants require medication for clinical conditions including cancer, cardiac defects and psychiatric disorders. In adults drug transfer from blood into brain is mostly restricted...
16.
Modepalli V, Kumar A, Sharp J, Saunders N, Nicholas K, Lefevre C
BMC Genomics
. 2018 Oct;
19(1):732.
PMID: 30290757
Background: After a short gestation, marsupials give birth to immature neonates with lungs that are not fully developed and in early life the neonate partially relies on gas exchange through...
17.
Saunders N, Dziegielewska K, Mollgard K, Habgood M
Annu Rev Pharmacol Toxicol
. 2018 Sep;
59:487-505.
PMID: 30183506
Efflux mechanisms situated in various brain barrier interfaces control drug entry into the adult brain; this review considers the effectiveness of these protective mechanisms in the embryo, fetus, and newborn...
18.
Saunders N, Dziegielewska K, Mollgard K, Habgood M
J Physiol
. 2018 May;
596(23):5723-5756.
PMID: 29774535
Properties of the local internal environment of the adult brain are tightly controlled providing a stable milieu essential for its normal function. The mechanisms involved in this complex control are...
19.
Mollgard K, Dziegielewska K, Holst C, Habgood M, Saunders N
Sci Rep
. 2017 Sep;
7(1):11603.
PMID: 28912477
Adult brain is protected from entry of drugs and toxins by specific mechanisms such as ABC (ATP-binding Cassette) efflux transporters. Little is known when these appear in human brain during...
20.
Saunders N, Dziegielewska K, Whish S, Hinds L, Wheaton B, Huang Y, et al.
F1000Res
. 2017 Jul;
6:921.
PMID: 28721206
: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent functional results from such studies can be translated to bipedal...