Noriaki Sasai
Overview
Explore the profile of Noriaki Sasai including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
1539
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Recent Articles
1.
Matsumoto Y, Tamaru S, Chen X, Shinozuka T, Sakumura Y, Sasai N
Dev Growth Differ
. 2025 Jan;
67(2):94-103.
PMID: 39825804
The neural tube, the embryonic precursor to the vertebrate central nervous system, comprises distinct progenitor and neuronal domains, each with specific proliferation programs. In this study, we identified TMEM196, a...
2.
Shigesada N, Shikada N, Shirai M, Toriyama M, Higashijima F, Kimura K, et al.
Cell Mol Life Sci
. 2024 Jan;
81(1):51.
PMID: 38252153
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction, affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable, because effective therapeutic methods have...
3.
Sasai N, Tada S, Ohshiro J, Kogiso C, Shinozuka T
Dev Growth Differ
. 2023 Nov;
66(1):89-100.
PMID: 38014908
During development, progenitor cell survival is essential for proper tissue functions, but the underlying mechanisms are not fully understood. Here we show that ERCC6L2, a member of the Snf2 family...
4.
Ong A, Kokaji T, Kishi A, Takihara Y, Shinozuka T, Shimamoto R, et al.
iScience
. 2023 Nov;
26(11):108257.
PMID: 37920664
[This corrects the article DOI: 10.1016/j.isci.2023.107887.].
5.
Ong A, Kokaji T, Kishi A, Takihara Y, Shinozuka T, Shimamoto R, et al.
iScience
. 2023 Sep;
26(10):107887.
PMID: 37771660
Neural induction is a process where naive cells are converted into committed cells with neural characteristics, and it occurs at the earliest step during embryogenesis. Although the signaling molecules and...
6.
Shinozuka T, Aoki M, Hatakeyama Y, Sasai N, Okamoto H, Takada S
Dev Dyn
. 2023 Sep;
253(4):435-446.
PMID: 37767857
Background: R-spondins (Rspos) are secreted proteins that modulate Wnt/β-catenin signaling. At the early stages of spinal cord development, Wnts (Wnt1, Wnt3a) and Rspos (Rspo1, Rspo3) are co-expressed in the roof...
7.
Matsukuma H, Kobayashi Y, Oka S, Higashijima F, Kimura K, Yoshihara E, et al.
Reprod Med Biol
. 2023 Jun;
22(1):e12514.
PMID: 37292088
Purpose: Spermatogenesis is a complex process orchestrated by several essential genes. (/PROM1) is a gene that is expressed in the testis but with a poorly understood role in spermatogenesis. Methods:...
8.
Yamamoto M, Ong A, Shinozuka T, Shirai M, Sasai N
Stem Cells
. 2023 Mar;
41(5):453-467.
PMID: 36866456
During development, the hypothalamus emerges from the ventral diencephalon and is regionalized into several distinct functional domains. Each domain is characterized by a different combination of transcription factors, including Nkx2.1,...
9.
Yamamoto M, Ong A, Shinozuka T, Sasai N
Dev Growth Differ
. 2022 Jun;
64(6):318-324.
PMID: 35700309
Understanding the molecular mechanisms leading to retinal development is of great interest for both basic scientific and clinical applications. Several signaling molecules and transcription factors involved in retinal development have...
10.
Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, et al.
Cell Prolif
. 2022 Mar;
55(4):e13215.
PMID: 35297517
Objectives: Mammalian DNA methyltransferases are essential to re-establish global DNA methylation patterns during implantation, which is critical for transmitting epigenetic information to the next generation. In contrast, the significance of...