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» Authors » Norbert C J de Wit

Norbert C J de Wit

Explore the profile of Norbert C J de Wit including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 166
Followers 0
Related Specialties
Hematology
Biochemistry
Pathology
Top 10 Co-Authors
Frans C S Ramaekers
Anton H N Hopman
Stefan G C Mestrum
Math P G Leers
Roosmarie J M Drent
Bert T Boonen
Wouter L W van Hemert
Eline M P Cremers
Steven Thornton
Erik A M Beckers
Published In
Clin Chem Lab Med
Leuk Res
Data Brief
Cytometry B Clin Cytom
J Clin Endocrinol Metab
Affiliations
Soon will be listed here.
Recent Articles
1.
Increased anti-apoptotic (Bcl-2+) and decreased proliferative (Ki-67+) cell fractions during the different maturation stages of bone marrow cell populations in MDS and AML: The potential diagnostic impact of the Bcl-2:Ki-67 ratio
Mestrum S, Schoenmakers T, Wang S, de Wit N, Boonen B, van Hemert W, et al.
Cytometry B Clin Cytom . 2025 Mar; PMID: 40051252
The relationship between apoptosis inhibition and cell proliferation was studied during the maturation stages of erythropoiesis, granulopoiesis, and monopoiesis in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)....
2.
MDS and AML show elevated fractions of CD34-positive blast cell populations with a high anti-apoptotic versus proliferation ratio
Mestrum S, Roanalis B, de Wit N, Drent R, Boonen B, van Hemert W, et al.
Leuk Res . 2024 May; 142:107520. PMID: 38776565
This study investigates the intertwined processes of (anti-)apoptosis and cell proliferation in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Utilizing antibodies to Bcl-2 and Ki-67, the CD34-positive blast cell...
3.
Impact of the gating strategy for Ki-67 and Bcl-2 on the determination of proliferation and anti-apoptosis data by flow cytometry in non-malignant bone marrow aspirates and aspirates from patients with myeloid malignancies
Mestrum S, Vanblarcum R, de Wit N, Drent R, Boonen B, van Hemert W, et al.
Data Brief . 2023 Jul; 49:109284. PMID: 37409174
This Data in Brief article displays a flow cytometric assay that was used for the acquisition and analyses of proliferative and anti-apoptotic activity in hematopoietic cells. This dataset includes analyses...
4.
Hypo-osmolality and its effect on erythrocyte parameters
Vroemen W, van Beers J, Frissen J, de Wit N
Int J Lab Hematol . 2023 Jan; 45(3):e93-e94. PMID: 36700927
No abstract available.
5.
The Proliferation Index of Erythroid Cells Predicts the Development of Transfusion-dependence in Myelodysplastic Syndrome Patients With Mildly Reduced Hemoglobin Levels at Initial Diagnosis
Mestrum S, de Wit N, Cremers E, Drent R, Ramaekers F, Hopman A, et al.
Hemasphere . 2022 Nov; 6(12):e804. PMID: 36382052
No abstract available.
6.
Optimized gating strategy and supporting flow cytometry data for the determination of the Ki-67 proliferation index in the diagnosis of myelodysplastic syndrome
Mestrum S, Cremers E, de Wit N, Drent R, Ramaekers F, Hopman A, et al.
Data Brief . 2022 Mar; 41:107976. PMID: 35252494
This Data in Brief article presents a novel flow cytometric assay used to acquire and process the data presented and discussed in the research paper by Mestrum et al., co-submitted...
7.
Integration of the Ki-67 proliferation index into the Ogata score improves its diagnostic sensitivity for low-grade myelodysplastic syndromes
Mestrum S, Cremers E, de Wit N, Drent R, Ramaekers F, Hopman A, et al.
Leuk Res . 2022 Feb; 113:106789. PMID: 35101793
Background: Although flow cytometric detection of myelodysplastic syndrome (MDS) with the Ogata score has a high specificity, its sensitivity for low-grade MDS is low. Additional markers are needed to improve...
8.
Proliferative activity is disturbed in myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), and MDS/MPN diseases. Differences between MDS and MDS/MPN
Mestrum S, de Wit N, Drent R, Hopman A, Ramaekers F, Leers M
Cytometry B Clin Cytom . 2020 Aug; 100(3):322-330. PMID: 32857909
The proliferation marker Ki-67 is widely used within the field of diagnostic histopathology as a prognostic marker for solid cancers. However, Ki-67 is hardly used for prognostic and diagnostic purposes...
9.
Multicenter study to evaluate a new enumeration method for hematopoietic stem cell collection management
Gromme M, Russcher H, Braakman E, Klinkspoor J, Dobber J, de Greef I, et al.
Transfusion . 2017 Jun; 57(8):1949-1955. PMID: 28653370
Background: CD34 flow cytometry is the gold standard for stem cell enumeration in peripheral blood at the mobilization stage and in the final apheresis product. The new stem cell mode...
10.
Within-day biological variation and hour-to-hour reference change values for hematological parameters
Hilderink J, Klinkenberg L, Aakre K, de Wit N, Henskens Y, van der Linden N, et al.
Clin Chem Lab Med . 2016 Dec; 55(7):1013-1024. PMID: 28002028
Background: Middle- and long-term biological variation data for hematological parameters have been reported in the literature. Within-day 24-h variability profiles for hematological parameters are currently lacking. However, comprehensive hour-to-hour variability...