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Noburu H Komiyama

Explore the profile of Noburu H Komiyama including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 1
Citations 0
Followers 0
Co-Authors
Seth G N Grant
Maxwell J Heinrich
Mark F Bear
Stephanie A Barnes
Peter S B Finnie
Aurore Thomazeau
Emily K Osterweil
Arnold J Heynen
Frank S Menniti
Published In
bioRxiv
Cell Rep
Affiliations
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Recent Articles
1.
Non-ionotropic signaling through the NMDA receptor GluN2B carboxy-terminal domain drives dendritic spine plasticity and reverses fragile X phenotypes
Barnes S, Thomazeau A, Finnie P, Heinrich M, Heynen A, Komiyama N, et al.
Cell Rep . 2025 Feb; :115311. PMID: 39983718
N-methyl-D-aspartate (NMDA)-induced spine shrinkage proceeds independently of ion flux and requires the initiation of de novo protein synthesis. Using subtype-selective pharmacological and genetic tools, we find that structural plasticity is...
2.
Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus
Barnes S, Thomazeau A, Finnie P, Heinrich M, Heynen A, Komiyama N, et al.
bioRxiv . 2025 Jan; PMID: 39764032
It is well known that activation of NMDA receptors can trigger long-term synaptic depression (LTD) and that a morphological correlate of this functional plasticity is spine retraction and elimination. Recent...