Nirmala Hariharan
Overview
Explore the profile of Nirmala Hariharan including associated specialties, affiliations and a list of published articles.
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27
Citations
2715
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Recent Articles
1.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
2.
Ebeid D, Khalafalla F, Broughton K, Monsanto M, Esquer C, Sacchi V, et al.
Cardiovasc Res
. 2020 Mar;
117(1):201-211.
PMID: 32176281
Aims: Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of cardiomyocytes...
3.
BIN1 Induces the Formation of T-Tubules and Adult-Like Ca Release Units in Developing Cardiomyocytes
de la Mata A, Tajada S, ODwyer S, Matsumoto C, Dixon R, Hariharan N, et al.
Stem Cells
. 2018 Oct;
37(1):54-64.
PMID: 30353632
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are at the center of new cell-based therapies for cardiac disease, but may also serve as a useful in vitro model for cardiac cell...
4.
Matsumoto C, Jiang Y, Emathinger J, Quijada P, Nguyen N, De La Torre A, et al.
Stem Cells
. 2018 Feb;
36(6):868-880.
PMID: 29441645
Aging severely limits myocardial repair and regeneration. Delineating the impact of age-associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We...
5.
Sacchi V, Wang B, Kubli D, Martinez A, Jin J, Alvarez Jr R, et al.
J Am Heart Assoc
. 2017 Oct;
6(10).
PMID: 29018025
Background: Aberrant Ca handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca handling is essential for the development of strategies to blunt...
6.
Samse K, Hariharan N, Sussman M
Pharmacol Res
. 2015 Nov;
103:13-6.
PMID: 26563999
During cardiac aging, DNA damage and environmental stressors contribute to telomeric shortening and human cardiac progenitor cells acquire a senescent phenotype that leads to decreased stem cell function. Reversion of...
7.
Quijada P, Hariharan N, Cubillo J, Bala K, Emathinger J, Wang B, et al.
J Biol Chem
. 2015 Sep;
290(42):25411-26.
PMID: 26324717
Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII) signaling in the heart regulates cardiomyocyte contractility and growth in response to elevated intracellular Ca(2+). The δB isoform of CaMKII is the predominant nuclear splice...
8.
Quijada P, Salunga H, Hariharan N, Cubillo J, El-Sayed F, Moshref M, et al.
Circ Res
. 2015 Aug;
117(8):695-706.
PMID: 26228030
Rationale: Dual cell transplantation of cardiac progenitor cells (CPCs) and mesenchymal stem cells (MSCs) after infarction improves myocardial repair and performance in large animal models relative to delivery of either...
9.
Gude N, Joyo E, Toko H, Quijada P, Villanueva M, Hariharan N, et al.
Basic Res Cardiol
. 2015 Apr;
110(3):29.
PMID: 25893875
Phase I clinical trials applying autologous progenitor cells to treat heart failure have yielded promising results; however, improvement in function is modest, indicating a need to enhance cardiac stem cell...
10.
Hariharan N, Sussman M
J Mol Cell Cardiol
. 2015 Apr;
83:32-6.
PMID: 25886698
Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention...