Nikolay A Krylov
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Explore the profile of Nikolay A Krylov including associated specialties, affiliations and a list of published articles.
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26
Citations
304
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Recent Articles
1.
Maryewski X, Krasilnikov M, Strakova P, Holoubek J, Frckova T, Panina I, et al.
ACS Appl Mater Interfaces
. 2025 Jan;
17(3):4502-4528.
PMID: 39772406
Enveloped viruses, such as flaviviruses and coronaviruses, are pathogens of significant medical concern that cause severe infections in humans. Some photosensitizers are known to possess virucidal activity against enveloped viruses,...
2.
Neuberger A, Shalygin A, Trofimov Y, Veretenenko I, Nadezhdin K, Krylov N, et al.
Structure
. 2024 Nov;
33(1):91-103.e5.
PMID: 39500315
TRPV6 is a Ca selective channel that mediates calcium uptake in the gut and contributes to the development and progression of human cancers. TRPV6 is represented by the ancestral and...
3.
Veretenenko I, Trofimov Y, Krylov N, Efremov R
Biochim Biophys Acta Biomembr
. 2024 Aug;
1866(7):184376.
PMID: 39111381
Lateral heterogeneity, or mosaicity, is a fundamental property inherent to cell membranes that is crucial for their functioning. While microscopic inhomogeneities (e.g. rafts) are easily detected experimentally, lipid domains with...
4.
Trofimov Y, Krylov N, Minakov A, Nadezhdin K, Neuberger A, Sobolevsky A, et al.
Commun Chem
. 2024 Jun;
7(1):119.
PMID: 38824263
Structural biology is solving an ever-increasing number of snapshots of ion channel conformational ensembles. Deciphering ion channel mechanisms, however, requires understanding the ensemble dynamics beyond the static structures. Here, we...
5.
Zavarzina I, Kuzmenkov A, Dobrokhotov N, Maleeva E, Korolkova Y, Peigneur S, et al.
FEBS Lett
. 2024 Apr;
598(8):889-901.
PMID: 38563123
BeKm-1 is a peptide toxin from scorpion venom that blocks the pore of the potassium channel hERG (K11.1) in the human heart. Although individual protein structures have been resolved, the...
6.
El-Mowafi S, Konshina A, Mohammed E, Krylov N, Efremov R, Parang K
Molecules
. 2023 Dec;
28(24).
PMID: 38138539
In our ongoing quest to design effective antimicrobial peptides (AMPs), this study aimed to elucidate the mechanisms governing cyclic amphiphilic AMPs and their interactions with membranes. The objective was to...
7.
Krylov N, Tabakmakher V, Yureva D, Vassilevski A, Kuzmenkov A
Protein Sci
. 2023 Sep;
32(11):e4776.
PMID: 37682529
Here, we introduce the third release of Kalium database (http://kaliumdb.org/), a manually curated comprehensive depository that accumulates data on polypeptide ligands of potassium channels. The major goal of this amplitudinous...
8.
Neuberger A, Trofimov Y, Yelshanskaya M, Khau J, Nadezhdin K, Khosrof L, et al.
Nat Commun
. 2023 Aug;
14(1):4630.
PMID: 37532722
The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological research in developing synthetic inhibitors of TRPV6, natural compounds acting at...
9.
Neuberger A, Trofimov Y, Yelshanskaya M, Nadezhdin K, Krylov N, Efremov R, et al.
Nat Commun
. 2023 May;
14(1):2659.
PMID: 37160865
Calcium-selective oncochannel TRPV6 is the major driver of cell proliferation in human cancers. While significant effort has been invested in the development of synthetic TRPV6 inhibitors, natural channel blockers have...
10.
Panina I, Krylov N, Chugunov A, Efremov R, Kordyukova L
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499114
S-acylation is a post-translational linkage of long chain fatty acids to cysteines, playing a key role in normal physiology and disease. In human cells, the reaction is catalyzed by a...