Nikolay A Aleksashin
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Explore the profile of Nikolay A Aleksashin including associated specialties, affiliations and a list of published articles.
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11
Citations
253
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Recent Articles
1.
Aleksashin N, Langeberg C, Shelke R, Yin T, Cate J
Nucleic Acids Res
. 2024 Dec;
53(3).
PMID: 39698810
West Nile virus (WNV) requires programmed -1 ribosomal frameshifting for translation of the viral genome. The efficiency of WNV frameshifting is among the highest known. However, it remains unclear why...
2.
Aleksashin N, Langeberg C, Shelke R, Yin T, Cate J
bioRxiv
. 2024 Oct;
PMID: 39464146
West Nile Virus (WNV), a member of the family, requires programmed -1 ribosomal frameshifting (PRF) for translation of the viral genome. The efficiency of WNV frameshifting is among the highest...
3.
Aleksashin N, Chang S, Cate J
RNA
. 2023 Oct;
29(12):1960-1972.
PMID: 37793791
Cell-free protein synthesis (CFPS) systems enable easy in vitro expression of proteins with many scientific, industrial, and therapeutic applications. Here we present an optimized, highly efficient human cell-free translation system...
4.
Aleksashin N, Chang S, Cate J
bioRxiv
. 2023 Feb;
PMID: 36798401
Cell-free protein synthesis (CFPS) systems enable easy expression of proteins with many scientific, industrial, and therapeutic applications. Here we present an optimized, highly efficient human cell-free translation system that bypasses...
5.
Zhang Y, Aleksashin N, Klepacki D, Anderson C, Vazquez-Laslop N, Gross C, et al.
Proc Natl Acad Sci U S A
. 2022 Jan;
119(4).
PMID: 35064089
Kasugamycin (KSG) is an aminoglycoside antibiotic widely used in agriculture and exhibits considerable medical potential. Previous studies suggested that KSG interferes with translation by blocking binding of canonical messenger RNA...
6.
Huang S, Aleksashin N, Loveland A, Klepacki D, Reier K, Kefi A, et al.
Nat Commun
. 2020 Jun;
11(1):2900.
PMID: 32518240
5S rRNA is an indispensable component of cytoplasmic ribosomes in all species. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear....
7.
Aleksashin N, Szal T, dAquino A, Jewett M, Vazquez-Laslop N, Mankin A
Nat Commun
. 2020 Apr;
11(1):1858.
PMID: 32313034
Ribosome engineering is a powerful approach for expanding the catalytic potential of the protein synthesis apparatus. Due to the potential detriment the properties of the engineered ribosome may have on...
8.
dAquino A, Azim T, Aleksashin N, Hockenberry A, Kruger A, Jewett M
Nucleic Acids Res
. 2020 Feb;
48(5):2777-2789.
PMID: 32009164
The synthetic capability of the Escherichia coli ribosome has attracted efforts to repurpose it for novel functions, such as the synthesis of polymers containing non-natural building blocks. However, efforts to...
9.
Aleksashin N, Leppik M, Hockenberry A, Klepacki D, Vazquez-Laslop N, Jewett M, et al.
Nat Commun
. 2019 Feb;
10(1):930.
PMID: 30804338
Ribo-T is an engineered ribosome whose small and large subunits are tethered together by linking 16S rRNA and 23S rRNA in a single molecule. Although Ribo-T can support cell proliferation...
10.
Polikanov Y, Aleksashin N, Beckert B, Wilson D
Front Mol Biosci
. 2018 Jun;
5:48.
PMID: 29868608
The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our current...