Nikolaos Tezapsidis
Overview
Explore the profile of Nikolaos Tezapsidis including associated specialties, affiliations and a list of published articles.
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14
Citations
613
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Recent Articles
1.
Johnston J, Hu W, Fardo D, Greco S, Perry G, Montine T, et al.
Curr Alzheimer Res
. 2013 Dec;
11(2):165-74.
PMID: 24359504
Analysis of data derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) program showed plasma leptin levels in individuals with Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD) to be lower...
2.
Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest
Greco S, Hamzelou A, Johnston J, Richardson S, Smith M, Perry G, et al.
Curr Alzheimer Res
. 2012 Sep;
9(10):1168-73.
PMID: 22950840
Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in...
3.
Johnston J, Greco S, Hamzelou A, Ashford J, Tezapsidis N
Therapy
. 2011 Nov;
8(5):481-490.
PMID: 22121334
The data from the initial clinical trials utilizing recombinant human leptin as an obesity therapy were published in 1998. Since then, numerous studies have been described which address dosage, safety...
4.
Greco S, Hamzelou A, Johnston J, Smith M, Ashford J, Tezapsidis N
Biochem Biophys Res Commun
. 2011 Sep;
414(1):170-4.
PMID: 21945934
Leptin is a pleiotropic hormone primarily secreted by adipocytes. A high density of functional Leptin receptors has been reported to be expressed in the hippocampus and other cortical regions of...
5.
Greco S, Bryan K, Sarkar S, Zhu X, Smith M, Ashford J, et al.
J Alzheimers Dis
. 2010 Mar;
19(4):1155-67.
PMID: 20308782
We have previously reported anti-amyloidogenic effects of leptin using in vitro and in vivo models and, more recently, demonstrated the ability of leptin to reduce tau phosphorylation in neuronal cells....
6.
Greco S, Bryan K, Sarkar S, Zhu X, Smith M, Ashford J, et al.
J Alzheimers Dis
. 2009 Dec;
PMID: 20009219
We have previously reported anti-amyloidogenic effects of leptin using in vitro and in vivo models and, more recently, demonstrated the ability of leptin to reduce tau phosphorylation in neuronal cells....
7.
Greco S, Sarkar S, Casadesus G, Zhu X, Smith M, Ashford J, et al.
Neurosci Lett
. 2009 May;
455(3):191-4.
PMID: 19429119
We have previously demonstrated that Leptin reduces extracellular amyloid beta (Abeta) protein both in vitro and in vivo, and intracellular tau phosphorylation in vitro. Further, we have shown that these...
8.
Tezapsidis N, Johnston J, Smith M, Ashford J, Casadesus G, Robakis N, et al.
J Alzheimers Dis
. 2009 Apr;
16(4):731-40.
PMID: 19387109
Adipocyte-derived leptin appears to regulate a number of features defining Alzheimer's disease (AD) at the molecular and physiological level. Leptin has been shown to reduce the amount of extracellular amyloid...
9.
Tezapsidis N, Smith M, Ashford J
Neurology
. 2009 Mar;
72(11):1030-1.
PMID: 19297682
No abstract available.
10.
Greco S, Sarkar S, Johnston J, Tezapsidis N
Biochem Biophys Res Commun
. 2009 Jan;
380(1):98-104.
PMID: 19166821
Leptin, which serves as a lipid-modulating hormone to control metabolic energy availability, is decreased in Alzheimer's disease (AD) patients, and serum levels are inversely correlated to severity of dementia. We...