Nigel J Temperton
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Explore the profile of Nigel J Temperton including associated specialties, affiliations and a list of published articles.
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42
Citations
1575
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Recent Articles
1.
Siwak K, LeBlanc E, Scott H, Kim Y, Pellizzari-Delano I, Ball A, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012365.
PMID: 39625989
Cell entry of severe acute respiratory coronavirus-2 (SARS-CoV-2) and other CoVs can occur via two distinct routes. Following receptor binding by the spike glycoprotein, membrane fusion can be triggered by...
2.
Klim H, William T, Mellors J, Brady C, Rajahram G, Chua T, et al.
Nat Commun
. 2024 Oct;
15(1):8863.
PMID: 39419988
Cases of H5 highly pathogenic avian influenzas (HPAI) are on the rise. Although mammalian spillover events are rare, H5N1 viruses have an estimated mortality rate in humans of 60%. No...
3.
Murugaiah V, Murugaiah V, Watson S, Watson S, Cunliffe R, Cunliffe R, et al.
J Infect Dis
. 2024 Sep;
231(2):e299-e307.
PMID: 39317662
The development of a universal influenza vaccine likely requires an understanding of previous exposure to influenza virus (through vaccination or infection) and how that shapes the antibody repertoire to vaccination,...
4.
Jenkins F, Mapulanga T, Thapa G, da Costa K, Temperton N
Pathogens
. 2024 Aug;
13(8).
PMID: 39204279
The emergence of SARS-CoV-2 has meant that pandemic preparedness has become a major focus of the global scientific community. Gathered in the historic St Edmund Hall college in Oxford, the...
5.
Rabeeah I, Billington E, Nal B, Sadeyen J, Pathan A, Iqbal M, et al.
Front Immunol
. 2024 May;
15:1352022.
PMID: 38698856
The complement system is an innate immune mechanism against microbial infections. It involves a cascade of effector molecules that is activated via classical, lectin and alternative pathways. Consequently, many pathogens...
6.
Fantoni T, Bissoli M, Stefani C, Voi M, Dabija A, Casula R, et al.
J Vis Exp
. 2023 Dec;
(201).
PMID: 38078607
Pseudotyped viruses (PVs) are molecular tools that can be used to study host-virus interactions and to test the neutralizing ability of serum samples, in addition to their better-known use in...
7.
Del Rosario J, da Costa K, Temperton N
Adv Exp Med Biol
. 2023 Mar;
1407:153-173.
PMID: 36920696
We have developed an influenza hemagglutinin (HA) pseudotype (PV) library encompassing all influenza A (IAV) subtypes from HA1-HA18, influenza B (IBV) subtypes (both lineages), representative influenza C (ICV), and influenza...
8.
da Costa K, Del Rosario J, Ferrari M, Vishwanath S, Asbach B, Kinsley R, et al.
Vaccines (Basel)
. 2022 Sep;
10(9).
PMID: 36146598
To better understand how inhibition of the influenza neuraminidase (NA) protein contributes to protection against influenza, we produced lentiviral vectors pseudotyped with an avian H11 hemagglutinin (HA) and the NA...
9.
Palmer P, Del Rosario J, da Costa K, Carnell G, Huang C, Heeney J, et al.
Front Immunol
. 2022 Feb;
12:681636.
PMID: 35222351
The emergence of COVID-19 has emphasised that biological assay data must be analysed quickly to develop safe, effective and timely vaccines/therapeutics. For viruses such as SARS-CoV-2, the primary way of...
10.
Du Y, Miah K, Habib O, Meyer-Berg H, Conway C, Viegas M, et al.
Thorax
. 2022 Feb;
77(12):1229-1236.
PMID: 35165144
Background: The COVID-19 pandemic continues to be a worldwide threat and effective antiviral drugs and vaccines are being developed in a joint global effort. However, some elderly and immune-compromised populations...