Nienke van der Werf
Overview
Explore the profile of Nienke van der Werf including associated specialties, affiliations and a list of published articles.
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11
Citations
374
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Recent Articles
1.
Tio D, Kasiem F, Willemsen M, van Doorn R, van der Werf N, Hoekzema R, et al.
Melanoma Res
. 2019 Jan;
29(4):349-357.
PMID: 30615012
The cancer/testis antigen (CTA) family is a group of antigens whose expression is restricted to male germline cells of the testis and various malignancies. This expression pattern makes this group...
2.
Redpath S, van der Werf N, MacDonald A, Maizels R, Taylor M
Infect Immun
. 2015 Jul;
83(10):3881-9.
PMID: 26195548
Foxp3(+) regulatory T (Treg) cells play a key role in suppression of immune responses during parasitic helminth infection, both by controlling damaging immunopathology and by inhibiting protective immunity. During the...
3.
van der Werf N, Redpath S, Azuma M, Yagita H, Taylor M
PLoS Pathog
. 2013 Mar;
9(3):e1003215.
PMID: 23516361
The suppression of protective Type 2 immunity is a principal factor driving the chronicity of helminth infections, and has been attributed to a range of Th2 cell-extrinsic immune-regulators. However, the...
4.
Redpath S, van der Werf N, Cervera A, MacDonald A, Gray D, Maizels R, et al.
Eur J Immunol
. 2013 Jan;
43(3):705-15.
PMID: 23319295
Foxp3(+) regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth...
5.
Taylor M, van der Werf N, Maizels R
Trends Immunol
. 2012 Mar;
33(4):181-9.
PMID: 22398370
Helminth parasites survive through a combination of parasite longevity, repeated re-infection and selective immune suppression to prevent protective Th2 responses. To counteract helminth-induced immunosuppression, and to induce long-term immunological memory,...
6.
van der Werf N, Redpath S, Phythian-Adams A, Azuma M, Allen J, Maizels R, et al.
J Immunol
. 2011 Jun;
187(3):1411-20.
PMID: 21705620
The immune suppression that characterizes human helminth infections can hinder the development of protective immunity or help to reduce pathogenic inflammation. Signaling through the T cell costimulator glucocorticoid-induced TNFR-related protein...
7.
Taylor M, van der Werf N, Harris A, Graham A, Bain O, Allen J, et al.
Eur J Immunol
. 2008 Dec;
39(1):192-206.
PMID: 19089814
Human helminth infections are synonymous with impaired immune responsiveness indicating suppression of host immunity. Using a permissive murine model of filariasis, Litomosoides sigmodontis infection of inbred mice, we demonstrate rapid...
8.
van der Werf N, Kroese F, Rozing J, Hillebrands J
Diabetes Metab Res Rev
. 2006 Nov;
23(3):169-83.
PMID: 17103489
During the last decades, the incidence of type 1 diabetes (T1D) has increased significantly, reaching percentages of 3% annually worldwide. This increase suggests that besides genetical factors environmental perturbations (including...
9.
van der Werf N, Hillebrands J, Klatter F, Bos I, Bruggeman C, Rozing J
Clin Dev Immunol
. 2004 Feb;
10(2-4):153-60.
PMID: 14768946
Background: Viral infections are thought to play a role in the development of autoimmune diseases like type 1 diabetes. In this study we investigated the effect of Rat Cytomegalovirus (RCMV)...
10.
Hillebrands J, van der Werf N, Klatter F, Bruggeman C, Rozing J
Clin Dev Immunol
. 2004 Feb;
10(2-4):133-9.
PMID: 14768944
Background: As one of the natural perturbants, infection with cytomegalovirus (CMV) is believed to play a role in the development of Type I diabetes. Using the DP-BB rat model for...