Nien-Jung Chen
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Explore the profile of Nien-Jung Chen including associated specialties, affiliations and a list of published articles.
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47
Citations
1307
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Recent Articles
1.
Tseng Y, Pan S, Huang J, Lee C, Hung J, Hsu P, et al.
Microb Cell
. 2024 Jul;
11:278.
PMID: 39081906
The PD-1/PD-L1 pathway plays a pivotal role in T cell activity and is involved in the pathophysiology of (MTB) infection. DNA methylation is a mechanism that modulates PD-L1 expression in...
2.
Wang H, Yang F, Yang C, Liu Y, Ko P, Li C, et al.
Exp Hematol Oncol
. 2023 Apr;
12(1):35.
PMID: 37029450
Introduction: Circulating monocytic myeloid-derived suppressive cells (M-MDSCs) are implicated as a poor prognostic factor and cause CAR T-cell failure in diffuse large B-cell lymphoma (DLBCL). Triggering receptors expressed on myeloid...
3.
Zhou T, Hsu H, Tu Y, Cheng H, Lin C, Chen N, et al.
Elife
. 2022 Nov;
11.
PMID: 36449334
Tissue-resident macrophages are essential to protect from pathogen invasion and maintain organ homeostasis. The ability of thymic macrophages to engulf apoptotic thymocytes is well appreciated, but little is known about...
4.
Weng S, Wen M, Hsieh S, Chen N, Tarng D
Front Immunol
. 2022 Jun;
13:879648.
PMID: 35720343
Background: Decoy receptor 3 (DcR3) belongs to the tumor necrosis factor (TNF) receptor superfamily and neutralizes TNF ligands, including FasL and TRAIL, to prevent T activation during T-cell priming. However,...
5.
Lin C, Chang T, Lu Y, Wu Y, Huang W, Lo W, et al.
J Mol Med (Berl)
. 2022 May;
100(6):917-931.
PMID: 35532794
Chronic kidney disease (CKD) is a global public health issue. CKD is caused by the infiltration of various myeloid cell types into renal tissue, resulting in renal fibrosis and tubular...
6.
Pan S, Shu C, Huang J, Lee C, Tseng Y, Hung J, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163542
The PD-1/PD-L1 pathway is critical in T cell biology; however, the role of the PD-1/PD-L1 pathway in clinical characteristics and treatment outcomes in pulmonary tuberculosis (PTB) patients is unclear. We...
7.
Jiang Z, Li H, Schroer S, Voisin V, Ju Y, Pacal M, et al.
EMBO J
. 2022 Jan;
41(4):e106825.
PMID: 35023164
Despite extensive analysis of pRB phosphorylation in vitro, how this modification influences development and homeostasis in vivo is unclear. Here, we show that homozygous Rb and Rb knock-in mice, in...
8.
Lo T, Chen H, Yao C, Weng I, Li C, Huang C, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(30).
PMID: 34301890
Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside-binding proteins, bind...
9.
Tseng W, Lee P, Tsai M, Chang F, Chen N, Chien C, et al.
Stem Cell Res Ther
. 2021 Jun;
12(1):367.
PMID: 34183058
Background: Acute kidney injury (AKI) is an emerging global healthcare issue without effective therapy yet. Autophagy recycles damaged organelles and helps maintain tissue homeostasis in acute renal ischemia-reperfusion (I/R) injury....
10.
Chen S, Hung Y, Fuh J, Chen N, Chu Y, Chen S, et al.
Stem Cell Reports
. 2021 Apr;
16(5):1363-1380.
PMID: 33836143
Microglia, the immune cells of the central nervous system, play critical roles in brain physiology and pathology. We report a novel approach that produces, within 10 days, the differentiation of...