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Niels Okkels

Explore the profile of Niels Okkels including associated specialties, affiliations and a list of published articles. Areas
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Articles 33
Citations 464
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Recent Articles
1.
Munk O, Rodell A, Danielsen P, Madsen J, Sorensen M, Okkels N, et al.
EJNMMI Phys . 2025 Feb; 12(1):11. PMID: 39899171
Purpose: Patients with dementia symptoms often struggle to limit movements during PET examinations, necessitating motion compensation in brain PET imaging to ensure the high image quality needed for diagnostic accuracy....
2.
Hansen F, Knudsen K, Damholdt M, Bek T, Borghammer P, Okkels N
Brain Commun . 2025 Jan; 7(1):fcaf002. PMID: 39845733
Asymmetric dopaminergic degeneration of the striatum is a characteristic feature of Parkinson's disease, associated with right-left asymmetry in motor function. As such, studying asymmetry provides insights into progressive neurodegeneration between...
3.
Labrador-Espinosa M, Silva-Rodriguez J, Okkels N, Munoz-Delgado L, Horsager J, Castro-Labrador S, et al.
Mol Psychiatry . 2024 Dec; PMID: 39639173
Cortical hypometabolism on FDG-PET is a well-established neuroimaging biomarker of cognitive impairment in Parkinson's disease (PD), but its pathophysiologic origins are incompletely understood. Cholinergic basal forebrain (cBF) degeneration is a...
4.
Horsager J, Andersen K, Okkels N, Knudsen K, Skjaerbaek C, Van Den Berge N, et al.
Parkinsonism Relat Disord . 2024 Sep; 127:107117. PMID: 39217795
Introduction: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric...
5.
Borghammer P, Okkels N, Weintraub D
J Parkinsons Dis . 2024 Jul; 14(5):1073-1074. PMID: 39031389
No abstract available.
6.
Borghammer P, Okkels N, Weintraub D
J Parkinsons Dis . 2024 Apr; 14(3):383-397. PMID: 38640172
The question whether Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are expressions of the same underlying disease has been vigorously debated for decades. The recently proposed biological...
7.
Okkels N, Grothe M, Taylor J, Hasselbalch S, Fedorova T, Knudsen K, et al.
Brain . 2024 Mar; 147(7):2308-2324. PMID: 38437860
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's disease, dementia with Lewy bodies, and isolated REM sleep behaviour disorder. Extensive research has demonstrated cholinergic alterations in the CNS...
8.
Okkels N, Horsager J, Fedorova T, Knudsen K, Skjaerbaek C, Andersen K, et al.
Brain . 2023 Nov; 147(1):255-266. PMID: 37975822
Dementia with Lewy bodies is characterized by a high burden of autonomic dysfunction and Lewy pathology in peripheral organs and components of the sympathetic and parasympathetic nervous system. Parasympathetic terminals...
9.
Okkels N, Horsager J, Labrador-Espinosa M, Kjeldsen P, Damholdt M, Mortensen J, et al.
Brain . 2023 Jun; 146(9):3690-3704. PMID: 37279796
Cholinergic changes play a fundamental role in the natural history of dementia with Lewy bodies and Lewy body disease in general. Despite important achievements in the field of cholinergic research,...
10.
Fedorova T, Knudsen K, Horsager J, Hansen A, Okkels N, Gottrup H, et al.
J Parkinsons Dis . 2023 May; 13(4):515-523. PMID: 37212074
Background: The α-syn Origin site and Connectome model (SOC) proposes that α-synucleinopathies can be divided into two categories: the asymmetrical brain-first, and more symmetrical body-first Lewy body disease. We have...