Jacob Horsager
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Explore the profile of Jacob Horsager including associated specialties, affiliations and a list of published articles.
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36
Citations
843
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Recent Articles
1.
Andersen K, Krishnamurthy A, Just M, Van Den Berge N, Skjaerbaek C, Horsager J, et al.
Nat Neurosci
. 2025 Mar;
PMID: 40082617
Recent studies suggest the existence of brain-first and body-first subtypes within the Lewy body disorder (LBD) spectrum, including Parkinson's disease. These studies primarily focused on α-synuclein propagation through the parasympathetic...
2.
Munk O, Rodell A, Danielsen P, Madsen J, Sorensen M, Okkels N, et al.
EJNMMI Phys
. 2025 Feb;
12(1):11.
PMID: 39899171
Purpose: Patients with dementia symptoms often struggle to limit movements during PET examinations, necessitating motion compensation in brain PET imaging to ensure the high image quality needed for diagnostic accuracy....
3.
Labrador-Espinosa M, Silva-Rodriguez J, Okkels N, Munoz-Delgado L, Horsager J, Castro-Labrador S, et al.
Mol Psychiatry
. 2024 Dec;
PMID: 39639173
Cortical hypometabolism on FDG-PET is a well-established neuroimaging biomarker of cognitive impairment in Parkinson's disease (PD), but its pathophysiologic origins are incompletely understood. Cholinergic basal forebrain (cBF) degeneration is a...
4.
Correlation between dopaminergic and metabolic asymmetry in Lewy body disease - A dual-imaging study
Horsager J, Andersen K, Okkels N, Knudsen K, Skjaerbaek C, Van Den Berge N, et al.
Parkinsonism Relat Disord
. 2024 Sep;
127:107117.
PMID: 39217795
Introduction: The a-Synuclein Origin and Connectome (SOC) model of Lewy body diseases postulates that a-syuclein will be asymmetrically distributed in some patients with Lewy body diseases, potentially leading to asymmetric...
5.
Ray Dorsey E, De Miranda B, Horsager J, Borghammer P
J Parkinsons Dis
. 2024 Apr;
14(3):363-381.
PMID: 38607765
The brain- and body-first models of Lewy body disorders predict that aggregated alpha-synuclein pathology usually begins in either the olfactory system or the enteric nervous system. In both scenarios the...
6.
Horsager J, Borghammer P
Parkinsonism Relat Disord
. 2024 Mar;
122:106101.
PMID: 38519273
We recently proposed a new disease model of Parkinson's disease - the a-Synuclein Origin site and Connectome model. The model posits that the initial pathology starts either in the olfactory...
7.
Okkels N, Grothe M, Taylor J, Hasselbalch S, Fedorova T, Knudsen K, et al.
Brain
. 2024 Mar;
147(7):2308-2324.
PMID: 38437860
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's disease, dementia with Lewy bodies, and isolated REM sleep behaviour disorder. Extensive research has demonstrated cholinergic alterations in the CNS...
8.
Okkels N, Horsager J, Fedorova T, Knudsen K, Skjaerbaek C, Andersen K, et al.
Brain
. 2023 Nov;
147(1):255-266.
PMID: 37975822
Dementia with Lewy bodies is characterized by a high burden of autonomic dysfunction and Lewy pathology in peripheral organs and components of the sympathetic and parasympathetic nervous system. Parasympathetic terminals...
9.
Okkels N, Horsager J, Labrador-Espinosa M, Kjeldsen P, Damholdt M, Mortensen J, et al.
Brain
. 2023 Jun;
146(9):3690-3704.
PMID: 37279796
Cholinergic changes play a fundamental role in the natural history of dementia with Lewy bodies and Lewy body disease in general. Despite important achievements in the field of cholinergic research,...
10.
Fedorova T, Knudsen K, Horsager J, Hansen A, Okkels N, Gottrup H, et al.
J Parkinsons Dis
. 2023 May;
13(4):515-523.
PMID: 37212074
Background: The α-syn Origin site and Connectome model (SOC) proposes that α-synucleinopathies can be divided into two categories: the asymmetrical brain-first, and more symmetrical body-first Lewy body disease. We have...