Niels Fischer
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Explore the profile of Niels Fischer including associated specialties, affiliations and a list of published articles.
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18
Citations
1732
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Recent Articles
1.
Petrychenko V, Yi S, Liedtke D, Peng B, Rodnina M, Fischer N
Nat Struct Mol Biol
. 2024 Sep;
32(1):62-72.
PMID: 39289545
The selection of an open reading frame (ORF) for translation of eukaryotic mRNA relies on remodeling of the scanning 48S initiation complex into an elongation-ready 80S ribosome. Using cryo-electron microscopy,...
2.
Yi S, Petrychenko V, Schliep J, Goyal A, Linden A, Chari A, et al.
Nucleic Acids Res
. 2022 Apr;
50(9):5282-5298.
PMID: 35489072
Selection of the translation start codon is a key step during protein synthesis in human cells. We obtained cryo-EM structures of human 48S initiation complexes and characterized the intermediates of...
3.
Petrychenko V, Peng B, de A P Schwarzer A, Peske F, Rodnina M, Fischer N
Nat Commun
. 2021 Oct;
12(1):5933.
PMID: 34635670
GTPases are regulators of cell signaling acting as molecular switches. The translational GTPase EF-G stands out, as it uses GTP hydrolysis to generate force and promote the movement of the...
4.
Yip K, Fischer N, Paknia E, Chari A, Stark H
Nature
. 2020 Oct;
587(7832):157-161.
PMID: 33087927
Single-particle electron cryo-microscopy (cryo-EM) is a powerful method for solving the three-dimensional structures of biological macromolecules. The technological development of transmission electron microscopes, detectors and automated procedures in combination with...
5.
Chan K, Petrychenko V, Mueller C, Maracci C, Holtkamp W, Wilson D, et al.
Nat Commun
. 2020 Aug;
11(1):4106.
PMID: 32796827
Alternative ribosome-rescue factor B (ArfB) rescues ribosomes stalled on non-stop mRNAs by releasing the nascent polypeptide from the peptidyl-tRNA. By rapid kinetics we show that ArfB selects ribosomes stalled on...
6.
Rodnina M, Fischer N, Maracci C, Stark H
Philos Trans R Soc Lond B Biol Sci
. 2017 Feb;
372(1716).
PMID: 28138068
Elongation factors Tu (EF-Tu) and SelB are translational GTPases that deliver aminoacyl-tRNAs (aa-tRNAs) to the ribosome. In each canonical round of translation elongation, aa-tRNAs, assisted by EF-Tu, decode mRNA codons...
7.
Fischer N, Neumann P, Bock L, Maracci C, Wang Z, Paleskava A, et al.
Nature
. 2016 Nov;
540(7631):80-85.
PMID: 27842381
In all domains of life, selenocysteine (Sec) is delivered to the ribosome by selenocysteine-specific tRNA (tRNA) with the help of a specialized translation factor, SelB in bacteria. Sec-tRNA recodes a...
8.
Hauer F, Gerle C, Fischer N, Oshima A, Shinzawa-Itoh K, Shimada S, et al.
Structure
. 2015 Aug;
23(9):1769-1775.
PMID: 26278176
We developed a method, named GraDeR, which substantially improves the preparation of membrane protein complexes for structure determination by single-particle cryo-electron microscopy (cryo-EM). In GraDeR, glycerol gradient centrifugation is used...
9.
Chari A, Haselbach D, Kirves J, Ohmer J, Paknia E, Fischer N, et al.
Nat Methods
. 2015 Aug;
12(9):859-65.
PMID: 26237227
Molecular machines or macromolecular complexes are supramolecular assemblies of biomolecules with a variety of functions. Structure determination of these complexes in a purified state is often tedious owing to their...
10.
Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome
Adio S, Senyushkina T, Peske F, Fischer N, Wintermeyer W, Rodnina M
Nat Commun
. 2015 Jun;
6:7442.
PMID: 26072700
The coupled translocation of transfer RNA and messenger RNA through the ribosome entails large-scale structural rearrangements, including step-wise movements of the tRNAs. Recent structural work has visualized intermediates of translocation...