Wolfgang Wintermeyer
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Explore the profile of Wolfgang Wintermeyer including associated specialties, affiliations and a list of published articles.
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59
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2391
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Recent Articles
1.
Bogeholz L, Mercier E, Wintermeyer W, Rodnina M
Methods Enzymol
. 2023 May;
684:39-70.
PMID: 37230593
Processing of newly synthesized polypeptides is essential for protein homeostasis and cell viability. In bacteria and eukaryotic organelles, all proteins are synthesized with formylmethionine at their N-terminus. As the nascent...
2.
Mercier E, Wang X, Bogeholz L, Wintermeyer W, Rodnina M
Front Mol Biosci
. 2022 May;
9:871121.
PMID: 35573737
Nascent polypeptides emerging from the ribosome during translation are rapidly scanned and processed by ribosome-associated protein biogenesis factors (RPBs). RPBs cleave the N-terminal formyl and methionine groups, assist cotranslational protein...
3.
Bogeholz L, Mercier E, Wintermeyer W, Rodnina M
Sci Rep
. 2021 Dec;
11(1):24457.
PMID: 34961771
Synthesis of bacterial proteins on the ribosome starts with a formylated methionine. Removal of the N-terminal formyl group is essential and is carried out by peptide deformylase (PDF). Deformylation occurs...
4.
Mercier E, Wang X, Maiti M, Wintermeyer W, Rodnina M
Proc Natl Acad Sci U S A
. 2021 Jun;
118(26).
PMID: 34162707
During synthesis of membrane proteins, transmembrane segments (TMs) of nascent proteins emerging from the ribosome are inserted into the central pore of the translocon (SecYEG in bacteria) and access the...
5.
Mercier E, Wintermeyer W, Rodnina M
EMBO J
. 2020 Apr;
39(15):e104054.
PMID: 32311161
Integral membrane proteins insert into the bacterial inner membrane co-translationally via the translocon. Transmembrane (TM) segments of nascent proteins adopt their native topological arrangement with the N-terminus of the first...
6.
Rodnina M, Peske F, Peng B, Belardinelli R, Wintermeyer W
Biol Chem
. 2019 Oct;
401(1):131-142.
PMID: 31600135
Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical function is to catalyze tRNA movement during translation elongation, but it also...
7.
Zaghouani M, Bogeholz L, Mercier E, Wintermeyer W, Roche S
Tetrahedron
. 2019 Sep;
75(24):3216-3230.
PMID: 31555018
A concise 7-step total synthesis of (±)-fumimycin in 11.6 % overall yield is reported. An acid-catalyzed intramolecular aza-Friedel-Crafts cyclization was developed to construct the benzofuranone skeleton of the natural product...
8.
Draycheva A, Lee S, Wintermeyer W
Sci Rep
. 2018 Jul;
8(1):9922.
PMID: 29967439
Membrane proteins in bacteria are cotranslationally inserted into the plasma membrane through the SecYEG translocon. Ribosomes exposing the signal-anchor sequence (SAS) of a membrane protein are targeted to the translocon...
9.
Mercier E, Holtkamp W, Rodnina M, Wintermeyer W
Nucleic Acids Res
. 2017 Nov;
45(20):11858-11866.
PMID: 29149347
The bacterial signal recognition particle (SRP) is part of the machinery that targets ribosomes synthesizing membrane proteins to membrane-embedded translocons co-translationally. Recognition of nascent membrane proteins occurs by virtue of...
10.
Ranjan A, Mercier E, Bhatt A, Wintermeyer W
Nat Commun
. 2017 May;
8:15562.
PMID: 28516953
Bacterial proteins are synthesized with an N-formylated amino-terminal methionine, and N-formylated peptides elicit innate-immunity responses against bacterial infections. However, the source of these formylated peptides is not clear, as most...