Niels D Prins
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Explore the profile of Niels D Prins including associated specialties, affiliations and a list of published articles.
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98
Citations
4203
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Recent Articles
1.
Dubbelman M, Vromen E, Tijms B, Berkhof J, Ottenhoff L, Vijverberg E, et al.
Alzheimers Dement (N Y)
. 2024 Aug;
10(3):e12485.
PMID: 39114370
Highlights: Pooling data from past Alzheimer's disease clinical trials may help identify subgroups most likely to benefit from specific treatments and may help inform future trial design.Accessing past trial datasets...
2.
Hey J, Abushakra S, Blennow K, Reiman E, Hort J, Prins N, et al.
Drugs
. 2024 Jun;
84(7):811-823.
PMID: 38902571
Introduction: ALZ-801/valiltramiprosate is a small-molecule oral inhibitor of beta amyloid (Aβ) aggregation and oligomer formation being studied in a phase 2 trial in APOE4 carriers with early Alzheimer's disease (AD)...
3.
Dubbelman M, Hendriksen H, Harrison J, Vijverberg E, Prins N, Kroeze L, et al.
Neurology
. 2024 Jan;
102(2):e207978.
PMID: 38165338
Background And Objectives: It is unclear to what extent cognitive outcome measures are sensitive to capture decline in Alzheimer disease (AD) prevention trials. We aimed to analyze the sensitivity to...
4.
Ottenhoff L, Vijverberg E, Visser L, Verijp M, Prins N, van der Flier W, et al.
Alzheimers Res Ther
. 2023 Apr;
15(1):72.
PMID: 37016435
Introduction: In the context of the development of pharmaceutical interventions, expectations and experiences of participants are essential. Their insights may be particularly helpful to address the challenges of recruiting and...
5.
Leijenaar J, Ingala S, Sudre C, Mutsaerts H, Leeuwis A, van der Flier W, et al.
Cereb Circ Cogn Behav
. 2022 Nov;
3:100128.
PMID: 36324417
Background: Patients with vascular cognitive impairment (VCI) are very heterogeneous in both symptoms and type of cerebrovascular pathology. This might be an important reason why there is no symptomatic treatment...
6.
Boomsma J, Exalto L, Barkhof F, Leeuwis A, Prins N, Scheltens P, et al.
Cereb Circ Cogn Behav
. 2022 Nov;
3:100141.
PMID: 36324410
Background: Little is known about the trajectories of cognitive decline in relation to different types of vascular brain injury in patients presenting at a memory clinic with Vascular Cognitive Impairment...
7.
Jiang Y, Alam J, Gomperts S, Maruff P, Lemstra A, Germann U, et al.
Nat Commun
. 2022 Sep;
13(1):5308.
PMID: 36130946
The endosome-associated GTPase Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α is...
8.
Verberk I, Laarhuis M, van den Bosch K, Ebenau J, van Leeuwenstijn M, Prins N, et al.
Lancet Healthy Longev
. 2022 Sep;
2(2):e87-e95.
PMID: 36098162
Background: Serum glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are putative non-amyloid blood-based biomarkers indicative of ongoing inflammatory and neurodegenerative disease processes. We aimed to assess their prognostic...
9.
Ebenau J, Visser D, Verfaillie S, Timmers T, van Leeuwenstijn M, Ten Kate M, et al.
Eur J Nucl Med Mol Imaging
. 2022 Sep;
50(2):410-422.
PMID: 36071221
Purpose: The role of cerebral blood flow (CBF) in the early stages of Alzheimer's disease is complex and largely unknown. We investigated cross-sectional and longitudinal associations between CBF, amyloid burden,...
10.
Waterink L, Bakker E, Visser L, Mangialasche F, Kivipelto M, Deckers K, et al.
Front Psychiatry
. 2022 Jun;
13:877460.
PMID: 35722572
Background: The COVID-19 pandemic has major influence on lifestyle and mental health, which might affect brain-health and increase the risk of cognitive decline, particularly in older adults. We aimed to...