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Nicole Beauchemin

Explore the profile of Nicole Beauchemin including associated specialties, affiliations and a list of published articles. Areas
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Articles 72
Citations 2458
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Recent Articles
1.
Dery K, Najjar S, Beauchemin N, Shively J, Kupiec-Weglinski J
Eur J Clin Invest . 2024 Dec; 54 Suppl 2:e14350. PMID: 39674874
Background: Alternative splicing is a fundamental mechanism in the post-transcriptional regulation of genes. The multifunctional transmembrane glycoprotein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) undergoes extensive alternative splicing to...
2.
Gandhi A, Huang Y, Sun Z, Kim W, Kondo Y, Hanley T, et al.
Eur J Clin Invest . 2024 Nov; 54 Suppl 2:e14357. PMID: 39555955
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a membrane protein that plays an important role in a variety of immune and non-immune functions. Such functions are regulated by its...
3.
Huang Y, Yoon C, Gandhi A, Hanley T, Castrillon C, Kondo Y, et al.
Commun Med (Lond) . 2024 Jul; 4(1):128. PMID: 38956268
Background: Human carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an inhibitory cell surface protein that functions through homophilic and heterophilic ligand binding. Its expression on immune cells in human...
4.
Kumar A, Laborit Labrada B, Lavallee-Bourget M, Forest M, Schwab M, Bellmann K, et al.
Mol Cell Biol . 2024 Jun; 44(7):261-272. PMID: 38828991
The protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1 (SHP-1) plays an important role in modulating glucose and lipid homeostasis. We previously suggested a potential role of SHP-1 in...
5.
Huang Y, Zhu C, Kondo Y, Anderson A, Gandhi A, Russell A, et al.
Nature . 2024 Feb; 626(8001):E19. PMID: 38336833
No abstract available.
6.
Kumar A, Schwab M, Laborit Labrada B, Silveira M, Goudreault M, Fournier E, et al.
J Biol Chem . 2023 Aug; 299(9):105164. PMID: 37595871
We previously reported that the protein-tyrosine phosphatase SHP-1 (PTPN6) negatively regulates insulin signaling, but its impact on hepatic glucose metabolism and systemic glucose control remains poorly understood. Here, we use...
7.
Gandhi A, Sun Z, Huang Y, Kim W, Yang C, Petsko G, et al.
Commun Biol . 2022 Sep; 5(1):1042. PMID: 36180783
The human (h) CEACAM1 GFCC' face serves as a binding site for homophilic and heterophilic interactions with various microbial and host ligands. hCEACAM1 has also been observed to form oligomers...
8.
Saliba J, Coutaud B, Makhani K, Epstein Roth N, Jackson J, Park J, et al.
Oncogene . 2022 Jan; 41(11):1563-1575. PMID: 35091681
We investigated the role of the NFE2L3 transcription factor in inflammation-induced colorectal cancer. Our studies revealed that Nfe2l3 mice exhibit significantly less inflammation in the colon, reduced tumor size and...
9.
Robitaille J, Izzi L, Daniels E, Zelus B, Holmes K, Beauchemin N
Eur J Biochem . 2020 Sep; 264(2):534-544. PMID: 32952205
Biliary glycoproteins are members of the carcinoembryonic antigen (CEA) family and behave as cell adhesion molecules. The mouse genome contains two very similar genes, and , whereas the human and...
10.
Rayes R, Vourtzoumis P, Rjeily M, Seth R, Bourdeau F, Giannias B, et al.
J Immunol . 2020 Mar; 204(8):2285-2294. PMID: 32169849
Neutrophils promote tumor growth and metastasis at multiple stages of cancer progression. One mechanism through which this occurs is via release of neutrophil extracellular traps (NETs). We have previously shown...