Nicole A Kruh-Garcia
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Explore the profile of Nicole A Kruh-Garcia including associated specialties, affiliations and a list of published articles.
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20
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831
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Recent Articles
1.
Welsh J, Goberdhan D, ODriscoll L, Buzas E, Blenkiron C, Bussolati B, et al.
J Extracell Vesicles
. 2024 Feb;
13(2):e12404.
PMID: 38326288
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker...
2.
Mehaffy C, Ryan J, Kruh-Garcia N, Dobos K
Front Cell Infect Microbiol
. 2022 Jun;
12:912831.
PMID: 35719351
Tuberculosis (TB) remains a public health issue causing millions of infections every year. Of these, about 15% ultimately result in death. Efforts to control TB include development of new and...
3.
Ryan J, Dobos K, Kruh-Garcia N
J Vis Exp
. 2022 Jun;
(183).
PMID: 35661678
The role of extracellular vesicles (EVs) in the context of bacterial infection has emerged as a new avenue for understanding microbial physiology. Specifically, Mycobacterium tuberculosis (Mtb) EVs play a role...
4.
Estrada A, Valenti Z, Hehn G, Amorese A, Williams N, Balestrieri N, et al.
Am J Physiol Cell Physiol
. 2021 Dec;
322(2):C246-C259.
PMID: 34910603
Extracellular vesicles (EVs) are biomarkers and modifiers of human disease. EVs secreted by insulin-responsive tissues like skeletal muscle (SkM) and white adipose tissue (WAT) contribute to metabolic health and disease...
5.
Mehaffy C, Lucas M, Kruh-Garcia N, Dobos K
Methods Mol Biol
. 2021 Jul;
2314:533-548.
PMID: 34235669
The use of proteomic technologies to characterize and study the proteome of mycobacteria has provided important information in terms of function, diversity, protein-protein interactions, and host-pathogen interactions in Mycobacterium spp....
6.
Lucas M, Ryan J, Watkins J, Early K, Kruh-Garcia N, Mehaffy C, et al.
Methods Mol Biol
. 2021 Jul;
2314:77-107.
PMID: 34235649
The extraction and separation of native mycobacterial proteins remain necessary for antigen discovery, elucidation of enzymes to improve rational drug design, identification of physiologic mechanisms, use as reagents for diagnostics,...
7.
Mehaffy C, Kruh-Garcia N, Graham B, Jarlsberg L, Willyerd C, Borisov A, et al.
J Clin Microbiol
. 2020 Apr;
58(6).
PMID: 32245831
Identification of biomarkers for latent infection and risk of progression to tuberculosis (TB) disease are needed to better identify individuals to target for preventive therapy, predict disease risk, and potentially...
8.
Islam M, Hitchings R, Kumar S, Fontes F, Lott J, Kruh-Garcia N, et al.
ACS Infect Dis
. 2018 Nov;
5(1):55-62.
PMID: 30406991
The biosynthesis of tryptophan in Mycobacterium tuberculosis is initiated by the transformation of chorismate to anthranilate, catalyzed by anthranilate synthase (TrpE/TrpG). Five additional enzymes are required to complete tryptophan biosynthesis....
9.
Diaz G, Bridges C, Lucas M, Cheng Y, Schorey J, Dobos K, et al.
J Vis Exp
. 2018 May;
(134).
PMID: 29708539
Exosomes, a type of nanovesicle released from all cell types, can be isolated from any bodily fluid. The contents of exosomes, including proteins and RNAs, are unique to the cells...
10.
Russell T, Green L, Rice T, Kruh-Garcia N, Dobos K, De Groote M, et al.
J Clin Microbiol
. 2017 Aug;
55(10):3072-3088.
PMID: 28794178
Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents...