Nicolas Papadopoulos
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Explore the profile of Nicolas Papadopoulos including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
59
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Recent Articles
1.
Lordier L, Di Buduo C, Kauskot A, Balayn N, Lavenu-Bombled C, Baschieri F, et al.
Haematologica
. 2025 Mar;
PMID: 40045897
Bernard Soulier Syndrome (BSS) is a severe bleeding disorder with moderate to severe thrombocytopenia, giant platelets, and platelet dysfunction, caused by biallelic mutations in GP1BA, GP1BB, or GP9 genes. We...
2.
Mazhari Dorooee D, Ravez S, Vertommen D, Renault N, Papadopoulos N, Marteau R, et al.
Angew Chem Int Ed Engl
. 2025 Feb;
:e202500518.
PMID: 40019446
Lipid metabolism is essential for cellular homeostasis, and its disruption is linked to various diseases. Acyl-coenzyme A synthetase long-chain family member 4 (ACSL4), a pivotal enzyme in lipid metabolism, has...
3.
Song J, Lanikova L, Kim S, Papadopoulos N, Meznarich J, Constantinescu S, et al.
Am J Hematol
. 2024 Apr;
99(7):1220-1229.
PMID: 38629639
Polycythemia vera (PV) is a clonal disorder arising from the acquired somatic mutations of the JAK2 gene, including JAK2 or several others in exon 12. A 38-year-old female had a...
4.
Papadopoulos N, Pristavec A, Nedelec A, Levy G, Staerk J, Constantinescu S
Blood
. 2023 Aug;
142(21):1818-1830.
PMID: 37616564
The thrombopoietin receptor (TpoR) plays a central role in myeloproliferative neoplasms (MPNs). Mutations in JAK2, calreticulin, or TpoR itself drive the constitutive activation of TpoR and uncontrolled proliferation and differentiation...
5.
Defour J, Leroy E, Dass S, Balligand T, Levy G, Brett I, et al.
Elife
. 2023 Jun;
12.
PMID: 37338955
Dimerization of the thrombopoietin receptor (TpoR) is necessary for receptor activation and downstream signaling through activated Janus kinase 2. We have shown previously that different orientations of the transmembrane (TM)...
6.
Suelves N, Saleki S, Ibrahim T, Palomares D, Moonen S, Koper M, et al.
Acta Neuropathol Commun
. 2023 May;
11(1):82.
PMID: 37198698
Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood....
7.
Willekens C, Laplane L, Dagher T, Benlabiod C, Papadopoulos N, Lacout C, et al.
Leukemia
. 2023 Apr;
37(6):1287-1297.
PMID: 37100881
Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary...
8.
Papadopoulos N, Nedelec A, Derenne A, Sulea T, Pecquet C, Chachoua I, et al.
Nat Commun
. 2023 Apr;
14(1):1881.
PMID: 37019903
Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative neoplasms (MPN). In healthy cells, CALR transiently and non-specifically interacts with immature N-glycosylated proteins through its N-terminal domain. Conversely, CALR...
9.
Papadopoulos N, Suelves N, Perrin F, Vadukul D, Vrancx C, Constantinescu S, et al.
Biomedicines
. 2022 Nov;
10(11).
PMID: 36359274
Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous system, corresponding to protein aggregates that progressively spread...
10.
Pecquet C, Papadopoulos N, Balligand T, Chachoua I, Tisserand A, Vertenoeil G, et al.
Blood
. 2022 Nov;
141(8):917-929.
PMID: 36356299
Mutant calreticulin (CALR) proteins resulting from a -1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs)....