Nicolas H Piguel
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Explore the profile of Nicolas H Piguel including associated specialties, affiliations and a list of published articles.
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12
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163
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Recent Articles
1.
Zhang S, Zhang H, Forrest M, Zhou Y, Sun X, Bagchi V, et al.
Cell Genom
. 2023 Sep;
3(9):100399.
PMID: 37719141
The mechanistic tie between genome-wide association study (GWAS)-implicated risk variants and disease-relevant cellular phenotypes remains largely unknown. Here, using human induced pluripotent stem cell (hiPSC)-derived neurons as a neurodevelopmental model,...
2.
Piguel N, Sanders S, De Simone F, Martin-de-Saavedra M, McCoig E, Dionisio L, et al.
Front Mol Neurosci
. 2023 Mar;
16:1144066.
PMID: 36969554
Introduction: AnkG, encoded by the gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node...
3.
Forrest M, Dos Santos M, Piguel N, Wang Y, Hawkins N, Bagchi V, et al.
Nat Commun
. 2023 Feb;
14(1):825.
PMID: 36808153
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for...
4.
Parnell E, Culotta L, Forrest M, Jalloul H, Eckman B, Loizzo D, et al.
Biol Psychiatry
. 2022 Dec;
94(2):153-163.
PMID: 36581494
Background: Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human induced pluripotent stem...
5.
Piguel N, Yoon S, Gao R, Horan K, Garza J, Petryshen T, et al.
Neuropsychopharmacology
. 2022 Nov;
48(7):1000-1010.
PMID: 36376465
Bipolar disorder (BD) is a highly heritable mood disorder with intermittent episodes of mania and depression. Lithium is the first-in-line medication to treat BD, but it is only effective in...
6.
Yoon S, Piguel N, Penzes P
Exp Mol Med
. 2022 Jul;
54(7):867-877.
PMID: 35794211
Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ),...
7.
Homer1 promotes dendritic spine growth through ankyrin-G and its loss reshapes the synaptic proteome
Yoon S, Piguel N, Khalatyan N, Dionisio L, Savas J, Penzes P
Mol Psychiatry
. 2021 Jan;
26(6):1775-1789.
PMID: 33398084
Homer1 is a synaptic scaffold protein that regulates glutamatergic synapses and spine morphogenesis. HOMER1 knockout (KO) mice show behavioral abnormalities related to psychiatric disorders, and HOMER1 has been associated with...
8.
Gao R, Zaccard C, Shapiro L, Dionisio L, Martin-de-Saavedra M, Piguel N, et al.
Neurosci Lett
. 2019 Feb;
701:92-99.
PMID: 30779956
GABAergic interneurons are emerging as prominent substrates in the pathophysiology of multiple neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and epilepsy. Interneuron excitatory activity is influenced by 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)...
9.
Garza J, Qi X, Gjeluci K, Leussis M, Basu H, Reis S, et al.
Transl Psychiatry
. 2018 Jul;
8(1):135.
PMID: 30046097
The ankyrin 3 gene (ANK3) is a well-established risk gene for psychiatric illness, but the mechanisms underlying its pathophysiology remain elusive. We examined the molecular effects of disrupting brain-specific Ank3...
10.
Gao R, Piguel N, Melendez-Zaidi A, Martin-de-Saavedra M, Yoon S, Forrest M, et al.
Mol Psychiatry
. 2018 Apr;
23(9):1832-1850.
PMID: 29610457
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The...