Marc Dos Santos
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Explore the profile of Marc Dos Santos including associated specialties, affiliations and a list of published articles.
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17
Citations
264
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Recent Articles
1.
Dos Santos M, Forrest M, Bomba-Warczak E, Parnell E, Edassery S, Yang K, et al.
bioRxiv
. 2025 Jan;
PMID: 39763806
Neuronal connection dysfunction is a convergent cause of cognitive deficits in mental disorders. Cognitive processes are finely regulated at the synaptic level by membrane proteins, some of which are shed...
2.
Heck N, Dos Santos M
Adv Neurobiol
. 2023 Nov;
34:311-348.
PMID: 37962799
The central nervous system is composed of neural ensembles, and their activity patterns are neural correlates of cognitive functions. Those ensembles are networks of neurons connected to each other by...
3.
Zhang S, Zhang H, Forrest M, Zhou Y, Sun X, Bagchi V, et al.
Cell Genom
. 2023 Sep;
3(9):100399.
PMID: 37719141
The mechanistic tie between genome-wide association study (GWAS)-implicated risk variants and disease-relevant cellular phenotypes remains largely unknown. Here, using human induced pluripotent stem cell (hiPSC)-derived neurons as a neurodevelopmental model,...
4.
Yoon S, Dos Santos M, Forrest M, Pratt C, Khalatyan N, Mohler P, et al.
Cell Rep
. 2023 Jul;
42(7):112784.
PMID: 37428632
Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood. We find that mice with prenatal deletion in cortical excitatory...
5.
Forrest M, Dos Santos M, Piguel N, Wang Y, Hawkins N, Bagchi V, et al.
Nat Commun
. 2023 Feb;
14(1):825.
PMID: 36808153
Neuropsychiatric disorders (NPDs) are frequently co-morbid with epilepsy, but the biological basis of shared risk remains poorly understood. The 16p11.2 duplication is a copy number variant that confers risk for...
6.
Parnell E, Culotta L, Forrest M, Jalloul H, Eckman B, Loizzo D, et al.
Biol Psychiatry
. 2022 Dec;
94(2):153-163.
PMID: 36581494
Background: Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human induced pluripotent stem...
7.
Parnell E, Voorn R, Martin-de-Saavedra M, Loizzo D, Dos Santos M, Penzes P
Front Mol Neurosci
. 2022 Dec;
15:994513.
PMID: 36533124
The Rac1 guanine exchange factor Kalirin-7 is a key regulator of dendritic spine morphology, LTP and dendritic arborization. Kalirin-7 dysfunction and genetic variation has been extensively linked to various neurodevelopmental...
8.
Burgdorf J, Yoon S, Dos Santos M, Lammert C, Moskal J, Penzes P
Mol Psychiatry
. 2022 Dec;
28(3):1101-1111.
PMID: 36481930
We developed an IGFBP2-mimetic peptide fragment, JB2, and showed that it promotes basal synaptic structural and functional plasticity in cultured neurons and mice. We demonstrate that JB2 directly binds to...
9.
Martin-de-Saavedra M, Dos Santos M, Penzes P
Trends Neurosci
. 2022 Apr;
45(6):483-498.
PMID: 35430102
Ectodomain shedding (ES) is a post-translational protein modification process that plays key roles in health and disease. Many neuronal and synaptic membrane proteins are known to undergo ES, but the...
10.
Martin-de-Saavedra M, Dos Santos M, Culotta L, Varea O, Spielman B, Parnell E, et al.
Neuron
. 2021 Dec;
110(4):627-643.e9.
PMID: 34921780
Although many neuronal membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in...