Nicolas Doucet
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Explore the profile of Nicolas Doucet including associated specialties, affiliations and a list of published articles.
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69
Citations
857
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Recent Articles
1.
Tran T, Narayanan C, Loes A, Click T, Pham N, Letourneau M, et al.
J Biol Chem
. 2024 Apr;
300(5):107280.
PMID: 38588810
Evolutionarily conserved structural folds can give rise to diverse biological functions, yet predicting atomic-scale interactions that contribute to the emergence of novel activities within such folds remains challenging. Pancreatic-type ribonucleases...
2.
Fuselier C, Dumoulin A, Pare A, Nehme R, Ajarrag S, de Boissel P, et al.
Cells
. 2023 Feb;
12(3).
PMID: 36766779
The first studies suggesting that abnormal expression of galectins is associated with cancer were published more than 30 years ago. Today, the role of galectins in cancer is relatively well...
3.
Bernard D, Narayanan C, Hempel T, Bafna K, Bhojane P, Letourneau M, et al.
Structure
. 2023 Jan;
31(3):329-342.e4.
PMID: 36649708
The evolutionary role of conformational exchange in the emergence and preservation of function within structural homologs remains elusive. While protein engineering has revealed the importance of flexibility in function, productive...
4.
Lemay-St-Denis C, Alejaldre L, Jemouai Z, Lafontaine K, St-Aubin M, Hitache K, et al.
Philos Trans R Soc Lond B Biol Sci
. 2023 Jan;
378(1871):20220040.
PMID: 36633286
We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were...
5.
Lemay-St-Denis C, Doucet N, Pelletier J
Protein Eng Des Sel
. 2022 Nov;
35.
PMID: 36416215
Enzyme engineering has become a widely adopted practice in research labs and industry. In parallel, the past decades have seen tremendous strides in characterizing the dynamics of proteins, using a...
6.
Bui D, Li Z, Kitov P, Han L, Kitova E, Fortier M, et al.
ACS Cent Sci
. 2022 Aug;
8(7):963-974.
PMID: 35912341
Electrospray ionization mass spectrometry (ESI-MS) is a powerful label-free assay for detecting noncovalent biomolecular complexes and is increasingly used to quantify binding thermochemistry. A common assumption made in ESI-MS affinity...
7.
Pham N, Letourneau M, Fortier M, Begin G, Al-Abdul-Wahid M, Pucci F, et al.
J Biol Chem
. 2021 Oct;
297(5):101308.
PMID: 34673030
The design of allosteric modulators to control protein function is a key objective in drug discovery programs. Altering functionally essential allosteric residue networks provides unique protein family subtype specificity, minimizes...
8.
Agarwal P, Bernard D, Bafna K, Doucet N
ChemCatChem
. 2021 Apr;
12(19):4704-4720.
PMID: 33897908
Conventional understanding of how enzymes function strongly emphasizes the role of structure. However, increasing evidence clearly indicates that enzymes do not remain fixed or operate exclusively in or close to...
9.
Dionne U, Bourgault E, Dube A, Bradley D, Chartier F, Dandage R, et al.
Nat Commun
. 2021 Mar;
12(1):1597.
PMID: 33712617
Protein-protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic binding specificities of the domains. The large family of SRC...
10.
Lopez de Los Santos Y, Bernard D, Egesborg P, Letourneau M, Lafortune C, Cuneo M, et al.
Biochemistry
. 2020 Nov;
59(48):4591-4600.
PMID: 33231438
The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their...