Nicolas Chartrel
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Explore the profile of Nicolas Chartrel including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
El Mehdi M, Takhlidjt S, Devere M, Arabo A, Le Solliec M, Maucotel J, et al.
Diabetologia
. 2022 Apr;
65(7):1198-1211.
PMID: 35476025
Aims/hypothesis: 26RFa (pyroglutamilated RFamide peptide [QRFP]) is a biologically active peptide that regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity at the periphery. 26RFa is...
12.
Le Solliec M, Arabo A, Takhlidjt S, Maucotel J, Devere M, Riancho J, et al.
Neuroendocrinology
. 2022 Jan;
112(11):1104-1115.
PMID: 35093951
Introduction: The aim of the study is to investigate whether acute or chronic central administration of the hypothalamic neuropeptide 26RFa may ameliorate the glycemic control of obese/diabetic mice. Methods: Mice...
13.
Duriez P, Nilsson I, Le Thuc O, Alexandre D, Chartrel N, Rovere C, et al.
Nutrients
. 2021 Aug;
13(8).
PMID: 34444945
Anorexia nervosa (AN) is a severe eating disorder where caloric restriction, excessive physical activity and metabolic alterations lead to life-threatening situations. Despite weight restoration after treatment, a significant part of...
14.
Lefranc B, Alim K, Neveu C, Le Marec O, Dubessy C, Boutin J, et al.
Molecules
. 2021 Jul;
26(14).
PMID: 34299587
26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior...
15.
El-Mehdi M, Takhlidjt S, Khiar F, Prevost G, do Rego J, Do Rego J, et al.
BMJ Open Diabetes Res Care
. 2020 Mar;
8(1).
PMID: 32114486
Introduction: 26RFa (pyroglutamyl RFamide peptide (QRFP)) is a biologically active peptide that has been found to control feeding behavior by stimulating food intake, and to regulate glucose homeostasis by acting...
16.
Prevost G, Picot M, Le Solliec M, Arabo A, Berrahmoune H, El Mehdi M, et al.
Endocr Connect
. 2019 Jun;
8(7):941-951.
PMID: 31234144
Objective: Recent studies performed in mice revealed that the neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity. However, in humans, an association between...
17.
Prevost G, Arabo A, Le Solliec M, Bons J, Picot M, Maucotel J, et al.
Am J Physiol Endocrinol Metab
. 2019 May;
317(1):E147-E157.
PMID: 31084498
Recent studies have shown that the hypothalamic neuropeptide 26RFa regulates glucose homeostasis by acting as an incretin and increasing insulin sensitivity. In this study, we further characterized the role of...
18.
Alim K, Lefranc B, Sopkova-de Oliveira Santos J, Dubessy C, Picot M, Boutin J, et al.
J Med Chem
. 2018 Oct;
61(22):10185-10197.
PMID: 30358997
26RFa, the endogenous QRFPR ligand, is implicated in several physiological and pathological conditions such as the regulation of glucose homeostasis and bone mineralization; hence, QRFPR ligands display therapeutic potential. At...
19.
Trebak F, Dubuc I, Picot M, Alaoui A, Leprince J, Prevost G, et al.
Neuroreport
. 2017 Sep;
28(16):1049-1053.
PMID: 28902709
EM66 is a peptide derived from the chromogranin, secretogranin II (SG-II). Recent findings in mice indicate that EM66 is a novel anorexigenic neuropeptide that regulates hypothalamic feeding behavior, at least...
20.
Chartrel N, Prevost G, El Medhi M, Arabo A, Berrahmoune H, Maucotel J, et al.
Biol Aujourdhui
. 2017 Mar;
210(4):227-235.
PMID: 28327281
The neuropeptide 26RFa, also referred to as QRFP (for pyroglutamilated RFamide peptide), is the latest member of the RFamide peptide family to be discovered. 26RFa and its N-extended form, 43RFa,...