Nicolas Carlos Hoch
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Explore the profile of Nicolas Carlos Hoch including associated specialties, affiliations and a list of published articles.
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9
Citations
82
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Recent Articles
1.
Chaves Ribeiro V, Russo L, Gonzalez Dure D, Hoch N
Biosci Rep
. 2025 Feb;
PMID: 40014063
Cells respond to a variety of internal and external stimuli by regulating the activities of different signalling cascades and cellular processes, often via chemical modifications of biological macromolecules that modulate...
2.
Moura R, Mattos P, Valente P, Hoch N
Genet Mol Biol
. 2024 Oct;
47Suppl 1(Suppl 1):e20230357.
PMID: 39356140
Regulated cell death by a non-apoptotic pathway known as parthanatos is increasingly recognised as a central player in pathological processes, including ischaemic tissue damage and neurodegenerative diseases. Parthanatos is activated...
3.
Latancia M, da Silva Leandro G, Bastos A, Moreno N, Ariwoola A, Martins D, et al.
DNA Repair (Amst)
. 2024 Jul;
141:103715.
PMID: 39029375
Glioblastoma (GBM) is a highly aggressive brain tumor associated with poor patient survival. The current standard treatment involves invasive surgery, radiotherapy, and chemotherapy employing temozolomide (TMZ). Resistance to TMZ is,...
4.
Matos I, Dallazen J, Reis L, Souza L, Bevevino R, de Moura R, et al.
J Med Chem
. 2024 Jul;
67(14):12012-12032.
PMID: 38991154
This study presents a new approach for identifying myeloperoxidase (MPO) inhibitors with strong in vivo efficacy. By combining inhibitor-like rules and structure-based virtual screening, the pipeline achieved a 70% success...
5.
Chaves Ribeiro V, Russo L, Hoch N
EMBO J
. 2024 Jun;
43(14):2908-2928.
PMID: 38834852
Protein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by...
6.
Martins D, di Lazzaro Filho R, Bertola D, Hoch N
Front Aging
. 2023 Nov;
4:1296409.
PMID: 38021400
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by a range of clinical symptoms, including poikiloderma, juvenile cataracts, short stature, sparse hair, eyebrows/eyelashes, nail dysplasia, and skeletal abnormalities....
7.
Latancia M, Moreno N, Leandro G, Chaves Ribeiro V, de Souza I, Vieira W, et al.
Mutat Res Genet Toxicol Environ Mutagen
. 2022 Jun;
878:503498.
PMID: 35649682
Human DNA polymerases can bypass DNA lesions performing translesion synthesis (TLS), a mechanism of DNA damage tolerance. Tumor cells use this mechanism to survive lesions caused by specific chemotherapeutic agents,...
8.
Russo L, Tomasin R, Matos I, Manucci A, Sowa S, Dale K, et al.
J Biol Chem
. 2021 Aug;
297(3):101041.
PMID: 34358560
SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for coronavirus pathogenesis and is thus an attractive target for drug development. This macrodomain is thought to counteract the...
9.
Hoch N, Lai X, Heierhorst J
Front Biosci (Schol Ed)
. 2013 Jan;
5(2):396-411.
PMID: 23277058
Fundamental aspects of eukaryotic molecular and cellular biology are extensively studied in the budding yeast Saccharomyces cerevisiae. Genome maintenance pathways are highly conserved and research into a number of human...
10.
Rosa R, Hoch N, Furtado G, Saffi J, Henriques J
Mutat Res
. 2007 Jun;
633(1):35-45.
PMID: 17590383
Diphenyl diselenide (DPDS) is an organoselenium compound with interesting pharmacological activities and various toxic effects. In previous reports, we demonstrated the pro-oxidant action and the mutagenic properties of this molecule...