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Nicolas B Gomez

Explore the profile of Nicolas B Gomez including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 5
Citations 77
Followers 0
Related Specialties
General Medicine
Biochemistry
Neurology
Top 10 Co-Authors
Sami J Barmada
Kaitlin Weskamp
Elizabeth M H Tank
Peter K Todd
Xiexiong Deng
Shameena Shahzad
Corey Stewart
Jacob Waksmacki
Michael Bekier
Yi-Ju Tseng
Published In
bioRxiv
J Clin Invest
Nucleic Acids Res
Brain
Cell Rep
Affiliations
Soon will be listed here.
Recent Articles
1.
TDP43 autoregulation gives rise to dominant negative isoforms that are tightly controlled by transcriptional and post-translational mechanisms
Dykstra M, Weskamp K, Gomez N, Waksmacki J, Tank E, Glineburg M, et al.
Cell Rep . 2025 Jan; 44(1):115113. PMID: 39792557
The nuclear RNA-binding protein TDP43 is integrally involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous studies uncovered N-terminal TDP43 isoforms that are predominantly...
2.
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms
Dykstra M, Weskamp K, Gomez N, Waksmacki J, Tank E, Glineburg M, et al.
bioRxiv . 2024 Jul; PMID: 39005384
The nuclear RNA-binding protein TDP43 is integrally involved in the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Previous studies uncovered N-terminal TDP43 isoforms that are predominantly...
3.
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
Tseng Y, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, et al.
Nucleic Acids Res . 2024 Feb; 52(10):5928-5949. PMID: 38412259
A GGGGCC (G4C2) hexanucleotide repeat expansion in C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), while a CGG trinucleotide repeat expansion in FMR1 leads to the neurodegenerative disorder Fragile...
4.
Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats
Tseng Y, Malik I, Deng X, Krans A, Jansen-West K, Tank E, et al.
bioRxiv . 2023 Jun; PMID: 37333274
A GGGGCC (G4C2) hexanucleotide repeat expansion in causes amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD), while a CGG trinucleotide repeat expansion in leads to the neurodegenerative disorder Fragile X-associated tremor/ataxia...
5.
TDP-43 stabilizes G3BP1 mRNA: relevance to amyotrophic lateral sclerosis/frontotemporal dementia
Sidibe H, Khalfallah Y, Xiao S, Gomez N, Fakim H, Tank E, et al.
Brain . 2021 Jun; 144(11):3461-3476. PMID: 34115105
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stress...
6.
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Weskamp K, Tank E, Miguez R, McBride J, Gomez N, White M, et al.
J Clin Invest . 2019 Nov; 130(3):1139-1155. PMID: 31714900
Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship between these phenomena remains poorly defined. Here, we showed...