Nick Z Lu
Overview
Explore the profile of Nick Z Lu including associated specialties, affiliations and a list of published articles.
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17
Citations
975
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Recent Articles
1.
Oakley R, Ramamoorthy S, Foley J, Busada J, Lu N, Cidlowski J
FASEB J
. 2018 Apr;
32(10):5258-5271.
PMID: 29672221
Glucocorticoids are primary stress hormones, and their synthetic derivatives are widely used clinically. The therapeutic efficacy of these steroids is limited by side effects and glucocorticoid resistance. Multiple glucocorticoid receptor...
2.
Banuelos J, Cao Y, Shin S, Bochner B, Avila P, Li S, et al.
PLoS One
. 2017 May;
12(5):e0177884.
PMID: 28542361
Glucocorticoids promote neutrophilic inflammation, the mechanisms of which are poorly characterized. Using a lipopolysaccharide (LPS)-induced acute murine lung injury model, we determined the role of granulocyte colony-stimulating factor (G-CSF) in...
3.
A hotspot in the glucocorticoid receptor DNA-binding domain susceptible to loss of function mutation
Banuelos J, Shin S, Lu N
Steroids
. 2015 Feb;
96:115-20.
PMID: 25676786
Glucocorticoids (GCs) are used to treat a variety of inflammatory disorders and certain cancers. However, GC resistance occurs in subsets of patients. We found that EL4 cells, a GC-resistant mouse...
4.
Revollo J, Oakley R, Lu N, Kadmiel M, Gandhavadi M, Cidlowski J
Sci Signal
. 2013 Dec;
6(304):ra103.
PMID: 24300895
Hairy and enhancer of split-1 (HES1) is a basic helix-loop-helix transcription factor that is a key regulator of development and organogenesis. However, little is known about the role of HES1...
5.
Bender I, Cao Y, Lu N
Mol Endocrinol
. 2013 Jul;
27(9):1577-87.
PMID: 23820903
Translational isoforms of the glucocorticoid receptor α (GR-A, -B, -C1, -C2, -C3, -D1, -D2, and -D3) have distinct tissue distribution patterns and unique gene targets. The GR-C3 isoform-expressing cells are...
6.
Cao Y, Bender I, Konstantinidis A, Shin S, Jewell C, Cidlowski J, et al.
Blood
. 2013 Jan;
121(9):1553-62.
PMID: 23297131
Although glucocorticoids are a profoundly important class of anti-inflammatory and immunosuppressive agents, their actions in dendritic cells (DCs) are not well understood. We found that dexamethasone, a potent glucocorticoid, selectively...
7.
Gross K, Lu N, Cidlowski J
Mol Cell Endocrinol
. 2008 Nov;
300(1-2):7-16.
PMID: 19000736
Glucocorticoid receptor agonists are mainstays in the treatment of various malignancies of hematological origin. Glucocorticoids are included in therapeutic regimens for their ability to stimulate intracellular signal transduction cascades that...
8.
Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor
Lu N, Collins J, Grissom S, Cidlowski J
Mol Cell Biol
. 2007 Aug;
27(20):7143-60.
PMID: 17682054
Glucocorticoids are widely used in the treatment of inflammatory and other diseases. However, high-dose or chronic administration often triggers troublesome side effects such as metabolic syndrome and osteoporosis. We recently...
9.
Lu N, Wardell S, Burnstein K, DeFranco D, Fuller P, Giguere V, et al.
Pharmacol Rev
. 2006 Nov;
58(4):782-97.
PMID: 17132855
No abstract available.
10.
Lu N, Cidlowski J
Trends Cell Biol
. 2006 May;
16(6):301-7.
PMID: 16697199
Glucocorticoids are necessary for life and are essential in all aspects of health and disease as they regulate processes from mitosis to apoptosis, from metabolism to growth and development. However,...