Nick E Le Brun
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Explore the profile of Nick E Le Brun including associated specialties, affiliations and a list of published articles.
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119
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2031
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Recent Articles
1.
Crack J, Le Brun N
Chem Sci
. 2024 Oct;
PMID: 39464610
The regulatory protein NsrR, a member of the Rrf2 protein superfamily, plays a major role in the cellular response to nitrosative stress in many benign and pathogenic bacteria. The homodimeric...
2.
Crack J, Le Brun N
Biochim Biophys Acta Mol Cell Res
. 2024 Oct;
1872(1):119865.
PMID: 39442807
The application of mass spectrometric methodologies has revolutionised biological chemistry, from identification through to structural and conformational studies of proteins and other macromolecules. Native mass spectrometry (MS), in which proteins...
3.
Olivieri P, Crack J, Lehmann A, Le Brun N, Leimkuhler S
RSC Chem Biol
. 2024 Oct;
PMID: 39372677
CyaY, the frataxin homolog of , plays an important role in ISC iron-sulfur cluster assembly through interactions with the cysteine desulfurase IscS, which regulate the supply of sulfur. IscS is...
4.
Olivieri P, Klabes M, Crack J, Lehmann A, Bennett S, Le Brun N, et al.
Microbiol Spectr
. 2024 Jul;
:e0094924.
PMID: 38980029
All sulfur transfer pathways generally have in common an l-cysteine desulfurase as the initial sulfur-mobilizing enzyme, which serves as a sulfur donor for the biosynthesis of numerous sulfur-containing biomolecules in...
5.
Li C, Crack J, Newton-Payne S, Murphy A, Chen X, Pinchbeck B, et al.
mLife
. 2024 May;
1(2):114-130.
PMID: 38817677
Marine algae and bacteria produce approximately eight billion tonnes of the organosulfur molecule dimethylsulfoniopropionate (DMSP) in Earth's surface oceans annually. DMSP is an antistress compound and, once released into the...
6.
Pullin J, Wilson M, Clemancey M, Blondin G, Bradley J, Moore G, et al.
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(15):8442-8450.
PMID: 38529354
Both O and HO can oxidize iron at the ferroxidase center (FC) of bacterioferritin (EcBfr) but mechanistic details of the two reactions need clarification. UV/Vis, EPR, and Mössbauer spectroscopies have...
7.
Pullin J, Bradley J, Moore G, Le Brun N, Wilson M, Svistunenko D
Angew Chem Weinheim Bergstr Ger
. 2024 Mar;
133(15):8457-8460.
PMID: 38505322
The iron redox cycle in ferritins is not completely understood. Bacterioferritins are distinct from other ferritins in that they contain haem groups. It is acknowledged that the two iron motifs...
8.
Bradley J, Bugg Z, Sackey A, Andrews S, Wilson M, Svistunenko D, et al.
Angew Chem Int Ed Engl
. 2024 Feb;
63(16):e202401379.
PMID: 38407997
Ferritins are multimeric cage-forming proteins that play a crucial role in cellular iron homeostasis. All H-chain-type ferritins harbour a diiron site, the ferroxidase centre, at the centre of a 4...
9.
Dodd E, Le Brun N
J Inorg Biochem
. 2024 Jan;
252:112457.
PMID: 38176366
NsrR from Streptomyces coelicolor is a bacterial nitric oxide (NO) sensor/nitrosative stress regulator as its primary function, and has been shown to have differential response at low, mid, and high...
10.
Stanfill S, Hecht S, Joerger A, Gonzalez P, Maia L, Rivas M, et al.
Crit Rev Toxicol
. 2023 Dec;
53(10):658-701.
PMID: 38050998
Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco products, including smokeless tobacco (ST), generally contain tobacco-specific -nitrosamines (TSNAs), such as '-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone (NNK),...