Nicholas Stephanopoulos
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Explore the profile of Nicholas Stephanopoulos including associated specialties, affiliations and a list of published articles.
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58
Citations
949
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Recent Articles
11.
Simmons C, Buchberger A, Henry S, Novacek A, Fahmi N, MacCulloch T, et al.
J Am Chem Soc
. 2023 Nov;
145(48):26075-26085.
PMID: 37987645
The structural analysis of guest molecules in rationally designed and self-assembling DNA crystals has proven an elusive goal since its conception. Oligonucleotide frameworks provide an especially attractive route toward studying...
12.
Simmons C, Buchberger A, Henry S, Novacek A, Fahmi N, MacCulloch T, et al.
bioRxiv
. 2023 Oct;
PMID: 37873139
The structural analysis of guest molecules in rationally designed and self-assembling DNA crystals has proven elusive since its conception. Oligonucleotide frameworks provide an especially attractive route towards studying DNA-binding molecules...
13.
Narayanan R, Prasad A, Buchberger A, Zou L, Bernal-Chanchavac J, MacCulloch T, et al.
Small
. 2023 Oct;
20(9):e2307585.
PMID: 37849034
The combination of multiple orthogonal interactions enables hierarchical complexity in self-assembled nanoscale materials. Here, efficient supramolecular polymerization of DNA origami nanostructures is demonstrated using a multivalent display of small molecule...
14.
Xu Y, Zheng R, Prasad A, Liu M, Wan Z, Zhou X, et al.
bioRxiv
. 2023 Oct;
PMID: 37790307
Multivalency enables nanostructures to bind molecular targets with high affinity. Although antibodies can be generated against a wide range of antigens, their shape and size cannot be tuned to match...
15.
Fumasi F, MacCulloch T, Bernal-Chanchavac J, Stephanopoulos N, Holloway J
bioRxiv
. 2023 Jul;
PMID: 37502890
The extracellular matrix is a highly dynamic environment, and the precise temporal presentation of biochemical signals is critical for regulating cell behavior during development, healing, and disease progression. To mimic...
16.
Hsu Y, Chen S, Bernal-Chanchavac J, Sharma B, Moghimianavval H, Stephanopoulos N, et al.
Chem Commun (Camb)
. 2023 Jun;
59(57):8806-8809.
PMID: 37365952
In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we...
17.
Hsu Y, Chen S, Bernal-Chanchavac J, Sharma B, Moghimianavval H, Stephanopoulos N, et al.
bioRxiv
. 2023 May;
PMID: 37205334
In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we...
18.
Zhang Z, Sponer J, Bussi G, Mlynsky V, Sulc P, Simmons C, et al.
J Chem Inf Model
. 2023 May;
63(9):2794-2809.
PMID: 37126365
Holliday junction (HJ) is a noncanonical four-way DNA structure with a prominent role in DNA repair, recombination, and DNA nanotechnology. By rearranging its four arms, HJ can adopt either closed...
19.
Buchberger A, Al-Amin M, Simmons C, Stephanopoulos N
Chembiochem
. 2023 Apr;
24(17):e202300223.
PMID: 37099451
Peptides and DNA are two of the most commonly used self-assembling biological molecules for the construction of nanomaterials. However, there are only a few examples that combine these two self-assembly...
20.
Buchberger A, Riker K, Bernal-Chanchavac J, Narayanan R, Simmons C, Fahmi N, et al.
ACS Appl Bio Mater
. 2022 Sep;
PMID: 36108278
The integration of proteins with DNA nanotechnology would enable materials with diverse applications in biology, medicine, and engineering. Here, we describe a method for the incorporation of bioactive fibronectin domain...