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Nicholas R Thomson

Explore the profile of Nicholas R Thomson including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 278
Citations 13956
Followers 0
Related Specialties
Microbiology
Genetics
Infectious Diseases
Top 10 Co-Authors
Julian Parkhill
Gordon Dougan
Stephen Baker
Kathryn E Holt
Simon R Harris
Michael A Quail
Francois-Xavier Weill
Kate S Baker
Alison E Mather
Helena M B Seth-Smith
Published In
Microb Genom
J Bacteriol
Nat Commun
BMC Genomics
Proc Natl Acad Sci U S A
Affiliations
Soon will be listed here.
Recent Articles
11.
Evolution and host-specific adaptation of
Weimann A, Dinan A, Ruis C, Bernut A, Pont S, Brown K, et al.
Science . 2024 Jul; 385(6704):eadi0908. PMID: 38963857
The major human bacterial pathogen causes multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven...
12.
Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium
Tran T, Sridhar S, Reece S, Lunguya O, Jacobs J, Van Puyvelde S, et al.
Nat Commun . 2024 Jun; 15(1):5074. PMID: 38871710
Antimicrobial resistance (AMR) is a growing public health crisis that requires innovative solutions. Current susceptibility testing approaches limit our ability to rapidly distinguish between antimicrobial-susceptible and -resistant organisms. Salmonella Typhimurium...
13.
Bright New Resources for Syphilis Research: Genetically Encoded Fluorescent Tags for and Sf1Ep Cells
Grillova L, Romeis E, Lieberman N, Tantalo L, Xu L, Molini B, et al.
bioRxiv . 2024 Jun; PMID: 38854070
Graphical Abstract: By employing genetic engineering, was modified to express GFP, and Sf1Ep cells to express mCherry on the cytoplasmic membrane and BFP in the nucleus. These new resources for...
14.
Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)
Cocker D, Sammarro M, Chidziwisano K, Elviss N, Jacob S, Kajumbula H, et al.
Wellcome Open Res . 2024 May; 7:55. PMID: 38817338
In sub-Saharan Africa (sSA), there is high morbidity and mortality from severe bacterial infection and this is compounded by antimicrobial resistance, in particular, resistance to 3rd-generation cephalosporins. This resistance is...
15.
Using 16s rRNA sequencing to characterize the microbiome of tropical cutaneous ulcer disease: insights into the microbial landscape and implications for diagnosis and treatment
Handley B, Sokana O, Addo K, Wagner J, Fookes M, Harding-Esch E, et al.
Microb Genom . 2024 May; 10(5). PMID: 38739120
Cutaneous ulcers are common in yaws-endemic areas. Although often attributed to ' subsp. and , quantitative PCR has highlighted a significant proportion of these ulcers are negative for both pathogens...
16.
Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and stresses the importance to include temporal patterns for vaccine design considerations
Heinz E, Pearse O, Zuza A, Bilima S, Msefula C, Musicha P, et al.
Genome Med . 2024 May; 16(1):67. PMID: 38711148
Background: Infections caused by multidrug-resistant gram-negative bacteria present a severe threat to global public health. The WHO defines drug-resistant Klebsiella pneumoniae as a priority pathogen for which alternative treatments are...
17.
Melioidosis in Patients with COVID-19 Exposed to Contaminated Tap Water, Thailand, 2021
Tantirat P, Chantarawichian Y, Taweewigyakarn P, Kripattanapong S, Jitpeera C, Doungngern P, et al.
Emerg Infect Dis . 2024 Mar; 30(4):791-794. PMID: 38526300
In September 2021, a total of 25 patients diagnosed with COVID-19 developed acute melioidosis after (median 7 days) admission to a COVID-19 field hospital in Thailand. Eight nonpotable tap water...
18.
Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in low-income and middle-income countries: a molecular diagnostics study
Pakdeerat S, Boonklang P, Angchagun K, Chomkatekaew C, Apichaidejudom N, Dokket Y, et al.
Lancet Microbe . 2024 Mar; 5(4):e379-e389. PMID: 38493790
Background: Melioidosis is a neglected but often fatal tropical disease. The disease has broad clinical manifestations, which makes diagnosis challenging and time consuming. To improve diagnosis, we aimed to evaluate...
19.
Genetic diversity, determinants, and dissemination of lineages implicated in melioidosis in northeast Thailand
Seng R, Chomkatekaew C, Tandhavanant S, Saiprom N, Phunpang R, Thaipadungpanit J, et al.
bioRxiv . 2023 Dec; PMID: 38106061
Melioidosis is an often-fatal neglected tropical disease caused by an environmental bacterium . However, our understanding of the disease-causing bacterial lineages, their dissemination, and adaptive mechanisms remains limited. To address...
20.
A sensor histidine kinase from a plant-endosymbiont bacterium restores the virulence of a mammalian intracellular pathogen
Chaves-Olarte E, Meza-Torres J, Herrera-Rodriguez F, Lizano-Gonzalez E, Suarez-Esquivel M, Baker K, et al.
Microb Pathog . 2023 Nov; 185:106442. PMID: 37944675
Alphaproteobacteria include organisms living in close association with plants or animals. This interaction relies partly on orthologous two-component regulatory systems (TCS), with sensor and regulator proteins modulating the expression of...