Nicholas R J Gascoigne
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Explore the profile of Nicholas R J Gascoigne including associated specialties, affiliations and a list of published articles.
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106
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2820
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Recent Articles
1.
Tan J, Tan J, Wang C, Wu L, Gascoigne N, Bhatt S
STAR Protoc
. 2025 Mar;
6(1):103685.
PMID: 40067824
T cell-based therapies hold immense promise, but their production remains time-consuming and technically complex. Here, we present a protocol that streamlines the activation and lentiviral transduction of primary human T ...
2.
Hamidinia M, Gu Y, Ser Z, Brzostek J, Tay N, Yap J, et al.
Cell Mol Life Sci
. 2025 Feb;
82(1):94.
PMID: 40009199
Over the last decades, organ transplantation has made rapid progress as a curative therapy for organ failure. However, the adaptive immune system-alloreactive T cells and antibodies targeting human leukocyte antigens...
3.
Kumar A, Low J, Lim J, Myint B, Sun X, Wu L, et al.
Biomaterials
. 2025 Jan;
317:123079.
PMID: 39842078
Transfection of proteins, mRNA, and chimeric antigen receptor (CAR) transgenes into immune cells remains a critical bottleneck in cell manufacturing. Current methods, such as viruses and bulk electroporation, are hampered...
4.
Murali T, Gu Y, Minhat R, Yap J, Wood K, Wang C, et al.
Front Immunol
. 2025 Jan;
15:1438285.
PMID: 39744638
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating...
5.
Long Y, Ang K, Sethi R, Liao S, Heng Y, van Olst L, et al.
Nat Methods
. 2024 Jun;
21(9):1658-1667.
PMID: 38907114
Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially...
6.
Ser Z, Gascoigne N, Macary P, Sobota R
STAR Protoc
. 2024 Mar;
5(1):102927.
PMID: 38431839
Cross-linking mass spectrometry (XL-MS) provides low-resolution structural information to model protein structures. Here, we present a protocol to identify cross-links of purified antibody binding to purified human leukocyte antigen (HLA)....
7.
8.
Hou B, Hu Y, Zhu Y, Wang X, Li W, Tang J, et al.
J Immunol
. 2023 Dec;
212(3):397-409.
PMID: 38088801
SHP-1 (Src homology region 2 domain-containing phosphatase 1) is a well-known negative regulator of T cells, whereas its close homolog SHP-2 is the long-recognized main signaling mediator of the PD-1...
9.
Wu L, Tan J, Gascoigne N
STAR Protoc
. 2023 Jul;
4(3):102445.
PMID: 37432856
Gene-of-interest (GOI) knockout is an important technique to study the genetic mechanisms of T cells. Here, we present a protocol to generate GOI double allele gene knockouts in primary human...
10.
Deng L, Wojciech L, Png C, Kioh Y, Ng G, Chan E, et al.
NPJ Biofilms Microbiomes
. 2023 May;
9(1):22.
PMID: 37185924
Blastocystis is a species complex that exhibits extensive genetic diversity, evidenced by its classification into several genetically distinct subtypes (ST). Although several studies have shown the relationships between a specific...