Nicholas Pervolarakis
Overview
Explore the profile of Nicholas Pervolarakis including associated specialties, affiliations and a list of published articles.
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13
Citations
965
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0
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Recent Articles
1.
Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt J, Farahat P, Nguyen Q, et al.
Sci Adv
. 2023 Jul;
9(27):eadd9984.
PMID: 37418531
Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation contributes to the development of fibrosis in muscle disease remains unclear. Here, we used single-cell transcriptomics to determine the...
2.
Coulis G, Jaime D, Guerrero-Juarez C, Kastenschmidt J, Farahat P, Nguyen Q, et al.
bioRxiv
. 2023 May;
PMID: 37131694
The monocytic/macrophage system is essential for skeletal muscle homeostasis, but its dysregulation contributes to the pathogenesis of muscle degenerative disorders. Despite our increasing knowledge of the role of macrophages in...
3.
Nee K, Ma D, Nguyen Q, Pein M, Pervolarakis N, Insua-Rodriguez J, et al.
Nat Genet
. 2023 Mar;
55(4):595-606.
PMID: 36914836
Women with germline BRCA1 mutations (BRCA1) have increased risk for hereditary breast cancer. Cancer initiation in BRCA1 is associated with premalignant changes in breast epithelium; however, the role of the...
4.
Nave C, Roberts L, Hwu P, Estrella J, Vo T, Nguyen T, et al.
J Neurosci
. 2021 May;
41(24):5173-5189.
PMID: 33931552
We developed a method for single-cell resolution longitudinal bioluminescence imaging of PERIOD (PER) protein and TIMELESS (TIM) oscillations in cultured male adult brains that captures circadian circuit-wide cycling under simulated...
5.
Hachey S, Movsesyan S, Nguyen Q, Burton-Sojo G, Tankazyan A, Wu J, et al.
Lab Chip
. 2021 Feb;
21(7):1333-1351.
PMID: 33605955
Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline highlights the need for improved, physiologically-relevant...
6.
Alshetaiwi H, Pervolarakis N, Nguyen Q, Kessenbrock K
Methods Mol Biol
. 2020 Nov;
2236:177-187.
PMID: 33237548
Single-cell transcriptomics is a powerful tool to study previously unrealized cellular heterogeneity at the resolution of individual cells. Most of the previous knowledge in cell biology is based on data...
7.
Pervolarakis N, Nguyen Q, Williams J, Gong Y, Gutierrez G, Sun P, et al.
Cell Rep
. 2020 Oct;
33(3):108273.
PMID: 33086071
The mammary epithelial cell (MEC) system is a bilayered ductal epithelium of luminal and basal cells, maintained by a lineage of stem and progenitor populations. Here, we used integrated single-cell...
8.
Alshetaiwi H, Pervolarakis N, McIntyre L, Ma D, Nguyen Q, Rath J, et al.
Sci Immunol
. 2020 Feb;
5(44).
PMID: 32086381
Myeloid-derived suppressor cells (MDSCs) are innate immune cells that acquire the capacity to suppress adaptive immune responses during cancer. It remains elusive how MDSCs differ from their normal myeloid counterparts,...
9.
Lawson D, Kessenbrock K, Davis R, Pervolarakis N, Werb Z
Nat Cell Biol
. 2018 Nov;
20(12):1349-1360.
PMID: 30482943
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to...
10.
Nguyen Q, Pervolarakis N, Nee K, Kessenbrock K
Front Cell Dev Biol
. 2018 Sep;
6:108.
PMID: 30234113
Single-cell transcriptomic technologies have emerged as powerful tools to explore cellular heterogeneity at the resolution of individual cells. Previous scientific knowledge in cell biology is largely limited to data generated...