Nicholas O Markham
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Explore the profile of Nicholas O Markham including associated specialties, affiliations and a list of published articles.
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20
Citations
321
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Recent Articles
1.
Green E, Kotrannavar S, Rutherford M, Lunnemann H, Kaur H, Heiser C, et al.
J Pathol
. 2025 Mar;
PMID: 40026233
Colorectal cancer (CRC) is responsible for over 900,000 annual deaths worldwide. Emerging evidence supports pro-carcinogenic bacteria in the colonic microbiome are at least promotional in CRC development and may be...
2.
Spencer P, Wang J, Smith E, Spiga L, Simmons A, Kim T, et al.
bioRxiv
. 2025 Jan;
PMID: 39803424
The structure and function of the mammalian gut vary by region, yet why inflammatory diseases manifest in specific regions and not others remains unclear. We use a TNF-overexpressing Crohn's disease...
3.
Brackman L, Jung M, Green E, Joshi N, Revetta F, McClain M, et al.
Gut Microbes
. 2024 Nov;
16(1):2430421.
PMID: 39588838
infection is the predominant risk factor for the development of gastric cancer. Risk is enhanced by specific virulence factors, diet, and the inflammatory response. Chronic activation of T helper (Th)...
4.
Siddiqi U, Lunnemann H, Childress K, Shupe J, Rutherford S, Farrow M, et al.
bioRxiv
. 2024 May;
PMID: 38798529
is a common cause of diarrhea and mortality, especially in immunosuppressed and hospitalized patients. is a toxin-mediated disease, but the host cell receptors for toxin B (TcdB) have only recently...
5.
Jacobse J, Pilat J, Li J, Brown R, Kwag A, Buendia M, et al.
Front Oncol
. 2024 Feb;
13:1276743.
PMID: 38375204
Introduction: The pro-inflammatory cytokine interleukin-23 (IL-23) has been implicated in colorectal cancer (CRC). Yet, the cell-specific contributions of IL-23 receptor (IL-23R) signaling in CRC remain unknown. One of the cell...
6.
Heiser C, Simmons A, Revetta F, McKinley E, Ramirez-Solano M, Wang J, et al.
Cell
. 2023 Dec;
186(25):5620-5637.e16.
PMID: 38065082
Colorectal cancer exhibits dynamic cellular and genetic heterogeneity during progression from precursor lesions toward malignancy. Analysis of spatial multi-omic data from 31 human colorectal specimens enabled phylogeographic mapping of tumor...
7.
Shelton C, Sing E, Mo J, Shealy N, Yoo W, Thomas J, et al.
Cell Host Microbe
. 2023 Oct;
31(10):1604-1619.e10.
PMID: 37794592
The mechanisms by which the early-life microbiota protects against environmental factors that promote childhood obesity remain largely unknown. Using a mouse model in which young mice are simultaneously exposed to...
8.
Lunnemann H, Shealy N, Reyzer M, Shupe J, Green E, Siddiqi U, et al.
Gut Microbes
. 2023 Mar;
15(1):2185029.
PMID: 36872510
The mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely...
9.
Drewes J, Chen J, Markham N, Knippel R, Domingue J, Tam A, et al.
Cancer Discov
. 2022 Jun;
12(8):1873-1885.
PMID: 35678528
Significance: Colorectal cancer is a leading cause of cancer and cancer-related deaths worldwide, with a multifactorial etiology that likely includes procarcinogenic bacteria. Using human colon cancer specimens, culturing, and murine...
10.
Chen B, Scurrah C, McKinley E, Simmons A, Ramirez-Solano M, Zhu X, et al.
Cell
. 2021 Dec;
184(26):6262-6280.e26.
PMID: 34910928
Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights when analyzed at high resolution. We present a single-cell...