Nicholas M Morton
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Explore the profile of Nicholas M Morton including associated specialties, affiliations and a list of published articles.
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79
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1785
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Recent Articles
11.
Suchacki K, Ramage L, Kwok T, Kelman A, McNeill B, Rodney S, et al.
Nat Metab
. 2023 Aug;
5(8):1319-1336.
PMID: 37537371
Activation of brown adipose tissue (BAT) in humans is a strategy to treat obesity and metabolic disease. Here we show that the serotonin transporter (SERT), encoded by SLC6A4, prevents serotonin-mediated...
12.
Wilkie S, Marcu D, Carter R, Morton N, Gonzalo S, Selman C
Aging (Albany NY)
. 2023 Jun;
15(12):5266-5278.
PMID: 37354210
Hutchinson-Gilford progeria syndrome (HGPS) is a rare human disease characterised by accelerated biological ageing. Current treatments are limited, and most patients die before 15 years of age. Hydrogen sulfide (HS)...
13.
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
Suchacki K, Thomas B, Ikushima Y, Chen K, Fyfe C, Tavares A, et al.
Elife
. 2023 Apr;
12.
PMID: 37096321
Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR's metabolic effects, including decreased adiposity and improved insulin sensitivity, are important for its broader health...
14.
Kentistou K, Luan J, Wittemans L, Hambly C, Klaric L, Kutalik Z, et al.
Nat Commun
. 2023 Jan;
14(1):307.
PMID: 36658113
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the...
15.
Simon M, Mikec S, Morton N, Atanur S, Konc J, Horvat S, et al.
Mamm Genome
. 2022 Nov;
34(1):12-31.
PMID: 36414820
Alternative polyadenylation (APA) determines mRNA stability, localisation, translation and protein function. Several diseases, including obesity, have been linked to APA. Studies have shown that single nucleotide polymorphisms in polyadenylation signals...
16.
Al-Dahmani Z, Li X, Wiggenhauser L, Ott H, Kruithof P, Lunev S, et al.
Sci Rep
. 2022 Jul;
12(1):12077.
PMID: 35840638
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, was initially discovered as a cyanide detoxification enzyme. However, it was recently also found to be a genetic predictor of resistance...
17.
Hughes R, Elliott R, Li X, Munro A, Makda A, Carter R, et al.
ACS Chem Biol
. 2022 Jun;
17(7):1876-1889.
PMID: 35696676
Esophageal adenocarcinoma is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the...
18.
Barton S, Magnani D, James O, Livesey M, Selvaraj B, James O, et al.
Brain Commun
. 2022 Mar;
3(4):fcab255.
PMID: 35350711
Oligodendrocytes are implicated in amyotrophic lateral sclerosis pathogenesis and display transactive response DNA-binding protein-43 (TDP-43) pathological inclusions. To investigate the cell autonomous consequences of TDP-43 mutations on human oligodendrocytes, we...
19.
Mikec S, Simon M, Morton N, Atanur S, Konc J, Dovc P, et al.
Mol Biol Rep
. 2022 Mar;
49(6):4619-4631.
PMID: 35347545
Background: Adipose tissue hypoxia and members of the hypoxia-inducible factor alpha (HIFA) are involved in development of obesity. However, the mechanism and functions of HIF3A, one of three HIFA paralogs,...
20.
Emilsson V, Gudmundsdottir V, Gudjonsson A, Jonmundsson T, Jonsson B, Karim M, et al.
Nat Commun
. 2022 Jan;
13(1):481.
PMID: 35079000
Circulating proteins can be used to diagnose and predict disease-related outcomes. A deep serum proteome survey recently revealed close associations between serum protein networks and common disease. In the current...