Nicholas M Morton
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Explore the profile of Nicholas M Morton including associated specialties, affiliations and a list of published articles.
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79
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1785
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Recent Articles
1.
Hsu S, Stephen L, Phadwal K, Dillon S, Carter R, Morton N, et al.
Kidney Int
. 2025 Feb;
PMID: 39922377
Chronic kidney disease-mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification and renal osteodystrophy (ROD). However, the pathophysiology of ROD remains unclear. Here we examine the hypothesis that stalled mitophagy...
2.
Sirey T, Roberts K, Haerty W, Bedoya-Reina O, Rogatti-Granados S, Tan J, et al.
Elife
. 2025 Feb;
14.
PMID: 39898985
No abstract available.
3.
Simon M, cater M, Kunej T, Morton N, Horvat S
Trends Genet
. 2024 Oct;
41(1):33-46.
PMID: 39414414
This review addresses the significant challenge of identifying causal genetic variants within quantitative trait loci (QTLs) for complex traits and diseases. Despite progress in detecting the ever-larger number of such...
4.
Liu H, Negoita F, Brook M, Sakamoto K, Morton N
Essays Biochem
. 2024 Sep;
68(4):467-478.
PMID: 39290133
Hydrogen sulfide (H2S) played a pivotal role in the early evolution of life on Earth before the predominance of atmospheric oxygen. The legacy of a persistent role for H2S in...
5.
Wang R, Gomez Salazar M, Prunonosa Cervera I, Coutts A, French K, Pinto M, et al.
Nat Commun
. 2024 Aug;
15(1):7483.
PMID: 39209825
Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency...
6.
Villalobos E, Miguelez-Crespo A, Morgan R, Ivatt L, Paul M, Simpson J, et al.
J Endocrinol
. 2024 Jun;
262(2).
PMID: 38829241
Glucocorticoids modulate glucose homeostasis, acting on metabolically active tissues such as liver, skeletal muscle, and adipose tissue. Intracellular regulation of glucocorticoid action in adipose tissue impacts metabolic responses to obesity....
7.
Lovdel A, Suchacki K, Roberts F, Sulston R, Wallace R, Thomas B, et al.
J Endocrinol
. 2024 May;
262(2).
PMID: 38805506
Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass in healthy humans. It increases in diverse conditions, including ageing, obesity, osteoporosis, glucocorticoid therapy, and notably, during caloric restriction...
8.
Simon M, Mikec S, Atanur S, Konc J, Morton N, Horvat S, et al.
Genes Genomics
. 2024 Mar;
46(5):557-575.
PMID: 38483771
Background: Analysing genomes of animal model organisms is widely used for understanding the genetic basis of complex traits and diseases, such as obesity, for which only a few mouse models...
9.
Myllymaki H, Kelly L, Elliot A, Carter R, Johansson J, Chang K, et al.
Oncogenesis
. 2024 Jan;
13(1):7.
PMID: 38272902
Otto Warburg described tumour cells as displaying enhanced aerobic glycolysis whilst maintaining defective oxidative phosphorylation (OXPHOS) for energy production almost 100 years ago [1, 2]. Since then, the 'Warburg effect'...
10.
Luo Y, Chatre L, Melhem S, Al-Dahmani Z, Homer N, Miedema A, et al.
Redox Biol
. 2023 Nov;
68:102965.
PMID: 38000344
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1) was discovered as an enzyme that detoxifies cyanide by conversion to thiocyanate (rhodanide) using thiosulfate as substrate; this rhodanese activity was subsequently identified to be...