Nicholas M Hiers
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Explore the profile of Nicholas M Hiers including associated specialties, affiliations and a list of published articles.
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6
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51
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Recent Articles
1.
Hiers N, Li L, Li T, Sheng P, Wang Y, Traugot C, et al.
bioRxiv
. 2024 Dec;
PMID: 39713366
While much is known about miRNA biogenesis and canonical miRNA targeting, relatively less is understood about miRNA decay. The major miRNA decay pathway in metazoans is mediated through target-directed miRNA...
2.
Hiers N, Li T, Traugot C, Xie M
Wiley Interdiscip Rev RNA
. 2024 Mar;
15(2):e1832.
PMID: 38448799
MicroRNAs (miRNAs) are small non-coding RNAs that play a fundamental role in enabling miRNA-mediated target repression, a post-transcriptional gene regulatory mechanism preserved across metazoans. Loss of certain animal miRNA genes...
3.
Wang Y, Traugot C, Bubenik J, Li T, Sheng P, Hiers N, et al.
Mol Cell
. 2023 Oct;
83(21):3818-3834.e7.
PMID: 37820733
N-methyladenosine (mA) modifications play crucial roles in RNA metabolism. How mA regulates RNA polymerase II (RNA Pol II) transcription remains unclear. We find that 7SK small nuclear RNA (snRNA), a...
4.
Sheng P, Li L, Li T, Wang Y, Hiers N, Mejia J, et al.
Nat Commun
. 2023 Apr;
14(1):2108.
PMID: 37055443
MicroRNAs (miRNA) load onto AGO proteins to target mRNAs for translational repression or degradation. However, miRNA degradation can be triggered when extensively base-paired with target RNAs, which induces confirmational change...
5.
Fields C, Li L, Hiers N, Li T, Sheng P, Huda T, et al.
PLoS Genet
. 2021 Dec;
17(12):e1009934.
PMID: 34914716
MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. One notable exception is the RNA...
6.
Li L, Sheng P, Li T, Fields C, Hiers N, Wang Y, et al.
Genes Dev
. 2021 Nov;
35(23-24):1595-1609.
PMID: 34819352
Binding of microRNAs (miRNAs) to mRNAs normally results in post-transcriptional repression of gene expression. However, extensive base-pairing between miRNAs and target RNAs can trigger miRNA degradation, a phenomenon called target...