Nicholas M Barnes
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Explore the profile of Nicholas M Barnes including associated specialties, affiliations and a list of published articles.
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67
Citations
1365
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Recent Articles
1.
Corsi-Zuelli F, Donohoe G, Griffiths S, Del-Ben C, Watson A, Burke T, et al.
Biol Psychiatry Glob Open Sci
. 2025 Feb;
5(2):100429.
PMID: 39911538
Background: Depressive and negative symptoms are related to poor functional outcomes in schizophrenia. Cognitive deficits, reduced brain cortical thickness and volumes, and inflammation may contribute to depressive and negative symptoms,...
2.
Lalousis P, Malaviya A, Khatibi A, Saberi M, Kambeitz-Ilankovic L, Haas S, et al.
Biol Psychiatry
. 2024 Jun;
96(7):615-622.
PMID: 38823495
Background: Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes, reflecting a potential transdiagnostic dimension. Previous investigations have focused on...
3.
Cochrane S, Rajagopal R, Sheffield D, Stewart F, Hathaway L, Barnes N, et al.
Front Toxicol
. 2024 May;
6:1335110.
PMID: 38737195
In toxicology, steps are being taken towards more mechanism-focused and human relevant approaches to risk assessment, requiring new approaches and methods. Additionally, there is increasing emphasis by regulators on risk...
4.
Anderson A, Alfahad N, Wimalachandra D, Bouzinab K, Rudzinska P, Wood H, et al.
Nat Commun
. 2024 Feb;
15(1):1124.
PMID: 38321058
The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and...
5.
Qureshi O, Sutton E, Bithell R, West S, Cutler R, McCluskey G, et al.
MAbs
. 2024 Jan;
16(1):2300155.
PMID: 38241085
Rozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format...
6.
Alexander S, Christopoulos A, Davenport A, Kelly E, Mathie A, Peters J, et al.
Br J Pharmacol
. 2023 Dec;
180 Suppl 2:S23-S144.
PMID: 38123151
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of...
7.
Palmer E, Griffiths S, Watkins B, Weetman T, Ottridge R, Patel S, et al.
Trials
. 2023 Oct;
24(1):646.
PMID: 37803384
Background: Depressive episodes are common after first-episode psychosis (FEP), affecting more than 40% of people, adding to individual burden, poor outcomes, and healthcare costs. If the risks of developing depression...
8.
Herniman S, Wood S, Khandaker G, Dazzan P, Pariante C, Barnes N, et al.
Transl Psychiatry
. 2023 Sep;
13(1):297.
PMID: 37723153
Attempts to delineate an immune subtype of schizophrenia have not yet led to the clear identification of potential treatment targets. An unbiased informatic approach at the level of individual immune...
9.
Lalousis P, Schmaal L, Wood S, L E P Reniers R, Cropley V, Watson A, et al.
Brain Behav Immun
. 2023 Jul;
113:166-175.
PMID: 37423513
Objective: Immune system dysfunction is hypothesised to contribute to structural brain changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed and there is a lack of evidence of...
10.
Foley E, Griffiths S, Murray A, Rogers J, Corsi-Zuelli F, Hickinbotham H, et al.
BMJ Open
. 2023 Mar;
13(3):e067944.
PMID: 36963796
Introduction: Evidence suggests a potentially causal role of interleukin 6 (IL-6), a pleiotropic cytokine that generally promotes inflammation, in the pathogenesis of psychosis. However, no interventional studies in patients with...