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» Authors » Nicholas L Bentley

Nicholas L Bentley

Explore the profile of Nicholas L Bentley including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 209
Followers 0
Related Specialties
Biochemistry
General Medicine
Oncology
Top 10 Co-Authors
Nigel Turner
Brenna Osborne
Magdalene K Montgomery
Patsie Polly
Corrine E Fiveash
Gregory J Cooney
Lindsay E Wu
Angie M Y Shum
Abhirup Das
Timothy C Tan
Published In
Physiol Genomics
Sci Rep
Aging Cell
Free Radic Biol Med
Oncotarget
Affiliations
Soon will be listed here.
Recent Articles
1.
SIRT2 transgenic over-expression does not impact lifespan in mice
Wu L, Fiveash C, Bentley N, Kang M, Govindaraju H, Barbour J, et al.
Aging Cell . 2023 Nov; 22(12):e14027. PMID: 38009412
The NAD -dependent deacylase family of sirtuin enzymes have been implicated in biological ageing, late-life health and overall lifespan, though of these members, a role for sirtuin-2 (SIRT2) is less...
2.
Protein hypoacylation induced by Sirt5 overexpression has minimal metabolic effect in mice
Bentley N, Fiveash C, Osborne B, Quek L, Ogura M, Inagaki N, et al.
Biochem Biophys Res Commun . 2018 Jul; 503(3):1349-1355. PMID: 30017194
Sirtuins are a family of evolutionary conserved enzymes that dynamically regulate cellular physiology. Mammals have 7 sirtuins, which are located in different cellular compartments. Sirt5, a sirtuin isoform located in...
3.
Proteomic profiling of skeletal and cardiac muscle in cancer cachexia: alterations in sarcomeric and mitochondrial protein expression
Shum A, Poljak A, Bentley N, Turner N, Tan T, Polly P
Oncotarget . 2018 May; 9(31):22001-22022. PMID: 29774118
Background: Cancer cachexia is observed in more than 50% of advanced cancer patients, and impairs quality of life and prognosis. A variety of pathways are likely to be dysregulated. Hence,...
4.
Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes
Chowdhury M, Turner N, Bentley N, Das A, Wu L, Richani D, et al.
Sci Rep . 2017 Jan; 7:40159. PMID: 28054648
Type 2 diabetes (T2D) is a global pandemic. Currently, the drugs used to treat T2D improve hyperglycemic symptom of the disease but the underlying mechanism causing the high blood glucose...
5.
Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species
Montgomery M, Brown S, Lim X, Fiveash C, Osborne B, Bentley N, et al.
Biochim Biophys Acta . 2016 Sep; 1861(11):1828-1839. PMID: 27591968
In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice displayed minimal deterioration in...
6.
The role of mitochondrial sirtuins in health and disease
Osborne B, Bentley N, Montgomery M, Turner N
Free Radic Biol Med . 2016 May; 100:164-174. PMID: 27164052
Mitochondria play a critical role in energy production, cell signalling and cell survival. Defects in mitochondrial function contribute to the ageing process and ageing-related disorders such as metabolic disease, cancer,...
7.
Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia
Shum A, Fung D, Corley S, McGill M, Bentley N, Tan T, et al.
Physiol Genomics . 2015 Sep; 47(12):588-99. PMID: 26395599
Cancer cachexia is a systemic, paraneoplastic syndrome seen in patients with advanced cancer. There is growing interest in the altered muscle pathophysiology experienced by cachectic patients. This study reports the...