Nicholas Keat
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Explore the profile of Nicholas Keat including associated specialties, affiliations and a list of published articles.
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10
Citations
464
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Recent Articles
1.
Dubash S, Barwick T, Kozlowski K, Rockall A, Khan S, Khan S, et al.
J Nucl Med
. 2024 Feb;
PMID: 38331457
There is a clinical need for F-labeled somatostatin analogs for the imaging of neuroendocrine tumors (NET), given the limitations of using [Ga]Ga-DOTA-peptides, particularly with regard to widespread accessibility. We have...
2.
Dubash S, Keat N, Kozlowski K, Barnes C, Allott L, Brickute D, et al.
Eur J Nucl Med Mol Imaging
. 2020 Mar;
47(11):2549-2561.
PMID: 32123971
Background: Fatty acids derived de novo or taken up from the extracellular space are an essential source of nutrient for cell growth and proliferation. Radiopharmaceuticals including C-acetate, and F-FAC (2-F-fluoroacetate),...
3.
Wadhwa P, Thielemans K, Efthimiou N, Wangerin K, Keat N, Emond E, et al.
Methods
. 2020 Feb;
185:110-119.
PMID: 32006678
This work demonstrates how computational and physical modelling of the positron emission tomography (PET) image acquisition process for a state-of-the-art integrated PET and magnetic resonance imaging (PET-MR) system can produce...
4.
Onega M, Parker C, Coello C, Rizzo G, Keat N, Ramada-Magalhaes J, et al.
Eur J Nucl Med Mol Imaging
. 2020 Jan;
47(4):958-966.
PMID: 31897589
Purpose: Integrin αβ belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of cancer and pulmonary fibrosis....
5.
Venkataraman A, Keat N, Myers J, Turton S, Mick I, Gunn R, et al.
EJNMMI Res
. 2018 Aug;
8(1):71.
PMID: 30062395
Background: We measured whole body distribution of C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline binding site. The purpose of this phase I study was to evaluate...
6.
Keat N, Kenny J, Chen K, Onega M, Garman N, Slack R, et al.
J Nucl Med Technol
. 2018 Feb;
46(2):136-143.
PMID: 29438002
The αβ integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αβ-binding peptide, derived from the foot and mouth virus (NAVPNLRGDLQVLAQKVART [A20FMDV2]), has been developed to...
7.
Clinical Translation of a Click-Labeled 18F-Octreotate Radioligand for Imaging Neuroendocrine Tumors
Dubash S, Keat N, Mapelli P, Twyman F, Carroll L, Kozlowski K, et al.
J Nucl Med
. 2016 May;
57(8):1207-13.
PMID: 27173162
Unlabelled: We conducted the first-in-human study of (18)F-fluoroethyl triazole [Tyr(3)] octreotate ((18)F-FET-βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution, dosimetry, and safety. Despite advances in clinical imaging, detection...
8.
Comley R, Salinas C, Mizrahi R, Vitcu I, Ng A, Hallett W, et al.
Mol Imaging Biol
. 2011 Nov;
14(4):517-21.
PMID: 22076076
Purpose: We measured the whole-body distribution of IV-injected [¹¹C]GSK215083, a new 5-HT₆ antagonist PET tracer, as a function of time in adult subjects, in order to determine the radiation exposure....
9.
Muramatsu Y, Ikeda S, Osawa K, Sekine R, Niwa N, Terada M, et al.
Nihon Hoshasen Gijutsu Gakkai Zasshi
. 2007 Jun;
63(5):534-45.
PMID: 17538218
Although many current CT scanners incorporate CT-AEC, performance evaluation is not standardized. This study evaluates the performance of the latest CT-AEC of each manufacturer with the aim of establishing a...
10.
Barrett J, Keat N
Radiographics
. 2004 Nov;
24(6):1679-91.
PMID: 15537976
Artifacts can seriously degrade the quality of computed tomographic (CT) images, sometimes to the point of making them diagnostically unusable. To optimize image quality, it is necessary to understand why...