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Nicholas J Walton

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Articles 11
Citations 191
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Recent Articles
1.
Shearer N, Walton N
Adv Exp Med Biol . 2015 Nov; 874:101-19. PMID: 26589215
This chapter examines the evidence that the ability of neuroendocrine hormones, notably norepinephrine and epinephrine, to stimulate bacterial growth in iron-restricted media is not limited to molecules with a catecholamine...
2.
Pin C, Rolfe M, Munoz-Cuevas M, Hinton J, Peck M, Walton N, et al.
BMC Syst Biol . 2009 Nov; 3:108. PMID: 19917103
Background: The aging process of bacteria in stationary phase is halted if cells are subcultured and enter lag phase and it is then followed by cellular division. Network science has...
3.
Bennett J, Bertin L, Moulton B, Fairlamb I, Brzozowski A, Walton N, et al.
Biochem J . 2008 May; 414(2):281-9. PMID: 18479250
HCHL (hydroxycinnamoyl-CoA hydratase-lyase) catalyses the biotransformation of feruloyl-CoA to acetyl-CoA and the important flavour-fragrance compound vanillin (4-hydroxy-3-methoxybenzaldehyde) and is exploited in whole-cell systems for the bioconversion of ferulic acid into...
4.
Crossley R, Gaskin D, Holmes K, Mulholland F, Wells J, Kelly D, et al.
Appl Environ Microbiol . 2007 Oct; 73(24):7819-25. PMID: 17965203
One of the pathways involved in the acquisition of the essential metal iron by bacteria involves the reduction of insoluble Fe(3+) to soluble Fe(2+), followed by transport of Fe(2+) to...
5.
Freestone P, Walton N, Haigh R, Lyte M
Int J Food Microbiol . 2007 Sep; 119(3):159-69. PMID: 17850907
The dietary constituents that may act, in the broadest sense, as co-factors to enable bacterial enteropathogens to replicate in gastrointestinal environments are still largely unknown. Recent work has demonstrated that...
6.
McQualter R, Chong B, Meyer K, Van Dyk D, OShea M, Walton N, et al.
Plant Biotechnol J . 2006 Dec; 3(1):29-41. PMID: 17168897
Sugarcane (Saccharum hybrids) was evaluated as a production platform for p-hydroxybenzoic acid using two different bacterial proteins (a chloroplast-targeted version of Escherichia coli chorismate pyruvate-lyase and 4-hydroxycinnamoyl-CoA hydratase/lyase from Pseudomonas...
7.
Leonard P, Brzozowski A, Lebedev A, Marshall C, Smith D, Verma C, et al.
Acta Crystallogr D Biol Crystallogr . 2006 Dec; 62(Pt 12):1494-501. PMID: 17139085
The crystal structure of hydroxycinnamoyl-CoA hydratase-lyase (HCHL) from Pseudomonas fluorescens AN103 has been solved to 1.8 A resolution. HCHL is a member of the crotonase superfamily and catalyses the hydration...
8.
Leonard P, Marshall C, Dodson E, Walton N, Grogan G
Acta Crystallogr D Biol Crystallogr . 2004 Dec; 60(Pt 12 Pt 2):2343-5. PMID: 15583385
4-Hydroxycinnamoyl-coenzyme A hydratase-lyase (HCHL), also called feruloyl-CoA hydratase-lyase (FCHL), from Pseudomonas fluorescens strain AN103 is an enzyme of the crotonase superfamily that catalyses the one-step conversion of the CoA thioesters...
9.
Illingworth C, Mayer M, Elliott K, Hanfrey C, Walton N, Michael A
FEBS Lett . 2003 Aug; 549(1-3):26-30. PMID: 12914918
We functionally identified the last remaining step in the plant polyamine biosynthetic pathway by expressing an Arabidopsis thaliana agmatine iminohydrolase cDNA in yeast. Inspection of the whole pathway suggests that...
10.
Walton N, Mayer M, Narbad A
Phytochemistry . 2003 Jun; 63(5):505-15. PMID: 12809710
Vanillin (4-hydroxy-3-methoxybenzaldehyde) is an important flavour and aroma molecule, but is also of interest because of its biogenetic relationship to the phenylpropanoid pathway and to other molecules of physiological significance,...