Nicholas J Sisco
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Explore the profile of Nicholas J Sisco including associated specialties, affiliations and a list of published articles.
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15
Citations
126
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Recent Articles
1.
Keeling E, Sisco N, McElvogue M, Borazanci A, Dortch R, Stokes A
Magn Reson Imaging
. 2024 Jul;
112:116-127.
PMID: 38971264
Purpose: Multi-echo, multi-contrast methods are increasingly used in dynamic imaging studies to simultaneously quantify R and R. To overcome the computational challenges associated with nonlinear least squares (NLSQ) fitting, we...
2.
Shalom E, Kim H, van der Heijden R, Ahmed Z, Patel R, Hormuth 2nd D, et al.
Magn Reson Med
. 2023 Dec;
91(5):1803-1821.
PMID: 38115695
Purpose: has often been proposed as a quantitative imaging biomarker for diagnosis, prognosis, and treatment response assessment for various tumors. None of the many software tools for quantification are standardized....
3.
Shekhar M, Terashi G, Gupta C, Sarkar D, Debussche G, Sisco N, et al.
Matter
. 2022 Jul;
4(10):3195-3216.
PMID: 35874311
Cryo-electron microscopy (EM) requires molecular modeling to refine structural details from data. Ensemble models arrive at low free-energy molecular structures, but are computationally expensive and limited to resolving only small...
4.
Sisco N, Wang P, Stokes A, Dortch R
PeerJ
. 2022 Apr;
10:e13043.
PMID: 35368333
Background: Magnetic resonance imaging (MRI) is used extensively to quantify myelin content, however computational bottlenecks remain challenging for advanced imaging techniques in clinical settings. We present a fast, open-source toolkit...
5.
Bergamino M, Keeling E, Baxter L, Sisco N, Walsh R, Stokes A
J Alzheimers Dis
. 2021 Nov;
85(1):395-414.
PMID: 34842185
Background: Imaging biomarkers are increasingly used in Alzheimer's disease (AD), and the identification of sex differences using neuroimaging may provide insight into disease heterogeneity, progression, and therapeutic targets. Objective: The...
6.
Sisco N, Borazanci A, Dortch R, Stokes A
Mult Scler J Exp Transl Clin
. 2021 Aug;
7(3):20552173211037002.
PMID: 34377529
Background: Multiple sclerosis is characterized by the formation of central nervous system demyelinating lesions with microvasculature inflammation. Objective: Evaluate how lesion cerebral perfusion relates to white matter microstructural integrity in...
7.
Kim M, Sisco N, Hilton J, Montano C, Castro M, Cherry B, et al.
Nat Commun
. 2020 Aug;
11(1):4169.
PMID: 32820172
Sensing and responding to temperature is crucial in biology. The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid compounds, including capsaicin. Despite significant interest,...
8.
Sisco N, Luu D, Kim M, Van Horn W
Biomolecules
. 2020 Apr;
10(3).
PMID: 32245175
Transient receptor potential (TRP) ion channels are polymodal receptors that have been implicated in a variety of pathophysiologies, including pain, obesity, and cancer. The capsaicin and heat sensor TRPV1, and...
9.
Sisco N, Helsell C, Van Horn W
Sci Rep
. 2019 Oct;
9(1):14128.
PMID: 31575973
TRPM8 is a member of the transient receptor potential ion channel family where it functions as a cold and pain sensor in humans and other higher organisms. Previous studies show...
10.
Hilton J, Salehpour T, Sisco N, Rath P, Van Horn W
J Biol Chem
. 2018 May;
293(24):9423-9434.
PMID: 29724821
Transient receptor potential melastatin 8 (TRPM8) is a cold-sensitive ion channel with diverse physiological roles. TRPM8 activity is modulated by many mechanisms, including an interaction with the small membrane protein...