Nicholas J Severs
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Explore the profile of Nicholas J Severs including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Gadelha C, Rothery S, Morphew M, McIntosh J, Severs N, Gull K
Proc Natl Acad Sci U S A
. 2009 Oct;
106(41):17425-30.
PMID: 19805090
A key feature of immune evasion for African trypanosomes is the functional specialization of their surface membrane in an invagination known as the flagellar pocket (FP), the cell's sole site...
12.
Buers I, Robenek H, Lorkowski S, Nitschke Y, Severs N, Hofnagel O
Arterioscler Thromb Vasc Biol
. 2009 Mar;
29(5):767-73.
PMID: 19286631
Objective: Uptake of lipids by macrophages (MPhi) leads to lipid droplet accumulation and foam cell formation. The PAT family proteins are implicated in lipid droplet formation, but the precise function...
13.
Kreuzberg M, Liebermann M, Segschneider S, Dobrowolski R, Dobrzynski H, Kaba R, et al.
J Mol Cell Cardiol
. 2009 Jan;
46(4):553-9.
PMID: 19168070
In the human heart connexin(Cx)40, Cx43 and Cx45-containing gap junctional channels electrically couple cardiomyocytes, forming a functional syncytium. In the mouse heart, additionally, Cx30.2-containing gap junctions have been detected in...
14.
Robenek H, Buers I, Hofnagel O, Robenek M, Troyer D, Severs N
Biochim Biophys Acta
. 2009 Jan;
1791(6):408-18.
PMID: 19118639
Our existing understanding of the structure, protein organization and biogenesis of the lipid droplet has relied heavily on microscopical techniques that lack resolution and the ability to preserve native cellular...
15.
Robenek H, Weissen-Plenz G, Severs N
J Cell Mol Med
. 2008 Sep;
12(6A):2519-21.
PMID: 18793348
Mutations in or ablation of the gene encoding caveolin-3, a protein of muscle cell caveolae, result in forms of muscular dystrophy and cardiomyopathy. Another member of the caveolin gene family,...
16.
Grikscheit K, Thomas N, Bruce A, Rothery S, Chan J, Severs N, et al.
Cell Commun Adhes
. 2008 Jul;
15(1):185-93.
PMID: 18649189
In the human heart, ventricular myocytes express connexin 43 (Cx43) and traces of Cx45. In congestive heart failure, Cx43 levels decrease, Cx45 levels increase and gap junction size decreases. To...
17.
Robenek H, Buers I, Hofnagel O, Lorkowski S, Severs N
J Cell Mol Med
. 2008 Jul;
13(7):1381-90.
PMID: 18624750
GFP-tagging is widely used as a molecular tool to localize and visualize the trafficking of proteins in cells but interpretation is frequently limited by the low resolution afforded by fluorescence...
18.
Severs N, Robenek H
Methods Cell Biol
. 2008 Jul;
88:181-204.
PMID: 18617035
The term freeze-fracture cytochemistry embraces a series of techniques which share the goal of chemical identification of the structural components viewed in freeze-fracture replicas. As one of the major features...
19.
Severs N, Bruce A, Dupont E, Rothery S
Cardiovasc Res
. 2008 Jun;
80(1):9-19.
PMID: 18519446
Gap junctions form the cell-to-cell pathways for propagation of the precisely orchestrated patterns of current flow that govern the regular rhythm of the healthy heart. As in most tissues and...
20.
Robenek H, Severs N
Biol Proced Online
. 2008 Apr;
10:9-19.
PMID: 18385807
Freeze-fracture electron microscopy is a technique for examining the ultrastructure of rapidly frozen biological samples by transmission electron microscopy. Of a range of approaches to freeze-fracture cytochemistry that have been...