Nicholas J Schork
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Explore the profile of Nicholas J Schork including associated specialties, affiliations and a list of published articles.
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356
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Recent Articles
11.
McGrouther C, Rangan A, Di Florio A, Elman J, Schork N, Kelsoe J
ArXiv
. 2024 May;
PMID: 38745705
Background: Bipolar Disorder (BD) is a complex disease. It is heterogeneous, both at the phenotypic and genetic level, although the extent and impact of this heterogeneity is not fully understood....
12.
Liang W, Beaulieu-Jones B, Smalley S, Snyder M, Goetz L, Schork N
Front Pharmacol
. 2024 Mar;
15:1348112.
PMID: 38545548
In recent years, the development of sensor and wearable technologies have led to their increased adoption in clinical and health monitoring settings. One area that is in early, but promising,...
13.
Don J, Schork A, Glusman G, Rappaport N, Cummings S, Duggan D, et al.
Geroscience
. 2024 Mar;
46(4):3911-3927.
PMID: 38451433
Large-scale genome-wide association studies (GWAS) strongly suggest that most traits and diseases have a polygenic component. This observation has motivated the development of disease-specific "polygenic scores (PGS)" that are weighted...
14.
Watanabe K, Wilmanski T, Baloni P, Robinson M, Garcia G, Hoopmann M, et al.
Commun Biol
. 2023 Nov;
6(1):1208.
PMID: 38012377
No abstract available.
15.
Venn-Watson S, Schork N
Nutrients
. 2023 Nov;
15(21).
PMID: 37960259
Pentadecanoic acid (C15:0) is an essential odd-chain saturated fatty acid with broad activities relevant to protecting cardiometabolic, immune, and liver health. C15:0 activates AMPK and inhibits mTOR, both of which...
16.
Schork N, Elman J
J Alzheimers Dis
. 2023 Sep;
95(3):915-929.
PMID: 37661888
Background: APOE is the largest genetic risk factor for Alzheimer's disease (AD), but there is a substantial polygenic component. Polygenic risk scores (PRS) can summarize small effects across the genome...
17.
Frazer K, Schork N
Cell Genom
. 2023 Jul;
3(7):100360.
PMID: 37492100
For the past few years, researchers in the Human Pangenome Reference Consortium (HPRC) have been working to catalog almost all human genomic diversity. Frazer and Schork preview an article recently...
18.
Watanabe K, Wilmanski T, Baloni P, Robinson M, Garcia G, Hoopmann M, et al.
Commun Biol
. 2023 Jul;
6(1):768.
PMID: 37481675
Aging manifests as progressive deteriorations in homeostasis, requiring systems-level perspectives to investigate the gradual molecular dysregulation of underlying biological processes. Here, we report systemic changes in the molecular regulation of...
19.
Frankel E, Podder A, Sharifi M, Pillai R, Belnap N, Ramsey K, et al.
Cells
. 2023 Jul;
12(10).
PMID: 37408271
Mutations of the X-linked gene encoding methyl-CpG-binding protein 2 () cause classical forms of Rett syndrome (RTT) in girls. A subset of patients who are recognized to have an overlapping...
20.
Reddy P, Sun Z, Wippel H, Baxter D, Swearingen K, Shteynberg D, et al.
bioRxiv
. 2023 Jul;
PMID: 37398146
Lyme disease, caused by an infection with the spirochete , is the most common vector-borne disease in North America. strains harbor extensive genomic and proteomic variability and further comparison is...