Nicholas J Hand
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Explore the profile of Nicholas J Hand including associated specialties, affiliations and a list of published articles.
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40
Citations
1065
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Recent Articles
1.
Deep metabolic phenotyping of humans with protein-altering variants in using a genome-first approach
Huang H, Vitali C, Zhang D, Hand N, Phillips M, Creasy K, et al.
JHEP Rep
. 2024 Dec;
7(1):101243.
PMID: 39687601
Background & Aim: An unbiased genome-first approach can expand the molecular understanding of specific genes in disease-agnostic biobanks for deeper phenotyping. represents a good candidate for this approach due to...
2.
Hand N
Cell Mol Gastroenterol Hepatol
. 2024 Feb;
17(5):881-882.
PMID: 38412973
No abstract available.
3.
Scorletti E, Saiman Y, Jeon S, Schneider C, Buyco D, Lin C, et al.
JHEP Rep
. 2023 Dec;
6(1):100902.
PMID: 38074507
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid droplets (LDs) within hepatocytes. Perilipin 2 (PLIN2) is the most abundant protein in hepatic LDs...
4.
Stankov S, Vitali C, Park J, Nguyen D, Mayne L, Englander S, et al.
medRxiv
. 2023 Mar;
PMID: 36865344
Background: Plasma triglycerides (TGs) are causally associated with coronary artery disease and acute pancreatitis. Apolipoprotein A-V (apoA-V, gene ) is a liver-secreted protein that is carried on triglyceride-rich lipoproteins and...
5.
Bi X, Stankov S, Lee P, Wang Z, Wu X, Li L, et al.
Arterioscler Thromb Vasc Biol
. 2022 Jul;
42(9):1139-1151.
PMID: 35861973
Background: Common genetic variation in close proximity to the gene are significantly associated with coronary artery disease as well as with plasma lipid traits. We recently demonstrated that hepatic inflammation...
6.
Vujkovic M, Ramdas S, Lorenz K, Guo X, Darlay R, Cordell H, et al.
Nat Genet
. 2022 Jun;
54(6):761-771.
PMID: 35654975
Nonalcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease. Using a proxy NAFLD definition of chronic elevation of alanine aminotransferase (cALT) levels without other liver diseases,...
7.
Conlon D, Schneider C, Ko Y, Rodrigues A, Guo K, Hand N, et al.
J Clin Invest
. 2022 Feb;
132(6).
PMID: 35113816
Genetic variants at the SORT1 locus in humans, which cause increased SORT1 expression in the liver, are significantly associated with reduced plasma levels of LDL cholesterol and apolipoprotein B (apoB)....
8.
Quiroz-Figueroa K, Vitali C, Conlon D, Millar J, Tobias J, Bauer R, et al.
J Clin Invest
. 2021 Nov;
131(22).
PMID: 34779419
Genetic variants near the TRIB1 gene are highly significantly associated with plasma lipid traits and coronary artery disease. While TRIB1 is likely causal of these associations, the molecular mechanisms are...
9.
Larsen L, van den Boogert M, Rios-Ocampo W, Jansen J, Conlon D, Chong P, et al.
Cell Mol Gastroenterol Hepatol
. 2021 Oct;
13(2):583-597.
PMID: 34626841
Background & Aims: Recently, novel inborn errors of metabolism were identified because of mutations in V-ATPase assembly factors TMEM199 and CCDC115. Patients are characterized by generalized protein glycosylation defects, hypercholesterolemia,...
10.
Abbey D, Conlon D, Rainville C, Elwyn S, Quiroz-Figueroa K, Billheimer J, et al.
Clin Transl Sci
. 2021 Jun;
14(4):1369-1379.
PMID: 34156146
Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis...