Nicholas J Croucher
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Explore the profile of Nicholas J Croucher including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Horsfield S, Fok B, Fu Y, Turner P, Lees J, Croucher N
Genome Res
. 2025 Mar;
PMID: 40037844
Serotype surveillance of (the pneumococcus) is critical for understanding the effectiveness of current vaccination strategies. However, existing methods for serotyping are limited in their ability to identify the co-carriage of...
2.
Ercoli G, Selway-Clarke H, Truijen D, Folkmanaite M, Oulton T, Norris-Grey C, et al.
Clin Transl Immunology
. 2024 Oct;
13(10):e70012.
PMID: 39416767
Objectives: Patients with rheumatoid arthritis (RA) have an increased susceptibility to infections, including those caused by . Why RA is associated with increased susceptibility to is poorly understood. This study...
3.
Derelle R, von Wachsmann J, Maklin T, Hellewell J, Russell T, Lalvani A, et al.
Genome Res
. 2024 Oct;
34(10):1661-1673.
PMID: 39406504
Sequence variation observed in populations of pathogens can be used for important public health and evolutionary genomic analyses, especially outbreak analysis and transmission reconstruction. Identifying this variation is typically achieved...
4.
King A, Kumar N, Mellor K, Hawkins P, McGee L, Croucher N, et al.
Microb Genom
. 2024 Aug;
10(8).
PMID: 39196267
Defining the population structure of a pathogen is a key part of epidemiology, as genomically related isolates are likely to share key clinical features such as antimicrobial resistance profiles and...
5.
Kuronen J, Horsfield S, Pontinen A, Mallawaarachchi S, Arredondo-Alonso S, Thorpe H, et al.
Genome Res
. 2024 Aug;
34(7):1081-1088.
PMID: 39134411
Studies of bacterial adaptation and evolution are hampered by the difficulty of measuring traits such as virulence, drug resistance, and transmissibility in large populations. In contrast, it is now feasible...
6.
Mallawaarachchi S, Tonkin-Hill G, Pontinen A, Calland J, Gladstone R, Arredondo-Alonso S, et al.
NAR Genom Bioinform
. 2024 Jun;
6(2):lqae061.
PMID: 38846349
Population genomics has revolutionized our ability to study bacterial evolution by enabling data-driven discovery of the genetic architecture of trait variation. Genome-wide association studies (GWAS) have more recently become accompanied...
7.
Lux J, Sanchez Garcia L, Chaparro Fernandez P, Laloli L, Licheri M, Gallay C, et al.
Sci Rep
. 2024 May;
14(1):12416.
PMID: 38816440
Klebsiella pneumoniae releases the peptides AKTIKITQTR and FNEMQPIVDRQ, which bind the pneumococcal proteins AmiA and AliA respectively, two substrate-binding proteins of the ABC transporter Ami-AliA/AliB oligopeptide permease. Exposure to these...
8.
Vieira A, Wan Y, Ryan Y, Li H, Guy R, Papangeli M, et al.
Nat Commun
. 2024 May;
15(1):3916.
PMID: 38729927
The UK observed a marked increase in scarlet fever and invasive group A streptococcal infection in 2022 with severe outcomes in children and similar trends worldwide. Here we report lineage...
9.
Lux J, Portmann H, Sanchez Garcia L, Erhardt M, Holivololona L, Laloli L, et al.
Commun Biol
. 2024 Apr;
7(1):425.
PMID: 38589539
Treatment of pneumococcal infections is limited by antibiotic resistance and exacerbation of disease by bacterial lysis releasing pneumolysin toxin and other inflammatory factors. We identified a previously uncharacterized peptide in...
10.
Croucher N
Microb Biotechnol
. 2024 Mar;
17(3):e14446.
PMID: 38536702
Developing protein-based vaccines against bacteria has proved much more challenging than producing similar immunisations against viruses. Currently, anti-bacterial vaccines are designed using methods based on reverse vaccinology. These identify broadly...